Sergey Ryazanov

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial​
    Levin, J.; Sing, N.; Melbourne, S.; Morgan, A.; Mariner, C.; Spillantini, M. G. & Wegrzynowicz, M. et al.​ (2022) 
    eBioMedicine, 80 art. S2352396422002055​.​ DOI: https://doi.org/10.1016/j.ebiom.2022.104021 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils​
    Antonschmidt, L.; Matthes, D. ; Dervişoğlu, R.; Frieg, B.; Dienemann, C. ; Leonov, A.   & Nimerovsky, E. et al.​ (2022) 
    Nature Communications, 13(1).​ DOI: https://doi.org/10.1038/s41467-022-32797-w 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates​
    Kuebler, L.; Buss, S.; Leonov, A. ; Ryazanov, S. ; Schmidt, F.; Maurer, A. & Weckbecker, D. et al.​ (2020) 
    European Journal of Nuclear Medicine and Molecular Imaging,.​ DOI: https://doi.org/10.1007/s00259-020-05133-x 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​
    Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.   & Ryazanov, S.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69744-y 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​
    Brendel, M.; Deussing, M.; Blume, T.; Kaiser, L.; Probst, F.; Overhoff, F. & Peters, F. et al.​ (2019) 
    Alzheimer's Research & Therapy, 11(1).​ DOI: https://doi.org/10.1186/s13195-019-0522-z 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers​
    Saravanan, M. S.; Ryazanov, S. ; Leonov, A. ; Nicolai, J.; Praest, P.; Giese, A. & Winter, R. et al.​ (2019) 
    Scientific Reports, 9(1).​ DOI: https://doi.org/10.1038/s41598-019-54919-z 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Iron-mediated aggregation and toxicity in a novel neuronal cell culture model with inducible alpha-synuclein expression​
    Bartels, M.; Weckbecker, D.; Kuhn, P.-H.; Ryazanov, S. ; Leonov, A. ; Griesinger, C.   & Lichtenthaler, S. F. et al.​ (2019) 
    Scientific Reports, 9(1).​ DOI: https://doi.org/10.1038/s41598-019-45298-6 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​
    Wegrzynowicz, M.; Bar-On, D.; Calo’, L.; Anichtchik, O.; Iovino, M.; Xia, J. & Ryazanov, S.  et al.​ (2019) 
    Acta Neuropathologica, 138(4) pp. 575​-595​.​ DOI: https://doi.org/10.1007/s00401-019-02023-x 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​The diphenylpyrazole compound anle138b blocks Aβ channels and rescues disease phenotypes in a mouse model for amyloid pathology​
    Martinez-Hernandez, A. ; Urbanke, H. ; Gillman, A. L.; Lee, J.; Ryazanov, S. ; Agbemenyah, H. Y.   & Benito, E.  et al.​ (2017) 
    EMBO molecular medicine, 10(1) pp. 32​-47​.​ DOI: https://doi.org/10.15252/emmm.201707825 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Treatment with diphenyl–pyrazole compound anle138b/c reveals that α-synuclein protects melanoma cells from autophagic cell death​
    Turriani, E.; Lázaro, D. F. ; Ryazanov, S. ; Leonov, A. ; Giese, A.; Schön, M.   & Schön, M. P.  et al.​ (2017) 
    Proceedings of the National Academy of Sciences of the United States of America, 114(25) pp. E4971​-E4977​.​ DOI: https://doi.org/10.1073/pnas.1700200114 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Photophysics of diphenyl-pyrazole compounds in solutions and α-synuclein aggregates​
    Reiner, A. M.; Schmidt, F.; Ryazanov, S. ; Leonov, A. ; Weckbecker, D.; Deeg, A. A. & Griesinger, C.  et al.​ (2017) 
    Biochimica et Biophysica Acta (BBA) - General Subjects, 1862(4) pp. 800​-807​.​ DOI: https://doi.org/10.1016/j.bbagen.2017.12.007 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Effect of the Novel Amyloid Inhibitor “anle145c” on Aggregation of Islet Amyloid Polypeptide and how it is Modulated by Membranes​
    Sadasivam, S. M.; Ryazanov, S. ; Leonov, A. ; Roeters, S.; Wouterson, S.; Giese, A. & Griesinger, C.  et al.​ (2016) 
    Biophysical Journal, 110(3) art. 420a​.​ DOI: https://doi.org/10.1016/j.bpj.2015.11.2271 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Anle138b Partly Ameliorates Motor Deficits Despite Failure of Neuroprotection in a Model of Advanced Multiple System Atrophy​
    Fellner, L.; Kuzdas-Wood, D.; Levin, J.; Ryazanov, S. ; Leonov, A. ; Griesinger, C.   & Giese, A. et al.​ (2016) 
    Frontiers in Neuroscience, 10 art. 99​.​ DOI: https://doi.org/10.3389/fnins.2016.00099 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies​
    Wagner, J. ; Krauss, S.; Shi, S.; Ryazanov, S. ; Steffen, J.; Miklitz, C. & Leonov, A.  et al.​ (2015) 
    Acta Neuropathologica, 130(5) pp. 619​-631​.​ DOI: https://doi.org/10.1007/s00401-015-1483-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Anle138b and related compounds are aggregation specific fluorescence markers and reveal high affinity binding to ot-synuclein aggregates​
    Deeg, A. A.; Reiner, A. M.; Schmidt, F.; Schueder, F.; Ryazanov, S. ; Ruf, V. C. & Giller, K.  et al.​ (2015) 
    Biochimica et Biophysica Acta (BBA) - General Subjects, 1850(9) pp. 1884​-1890​.​ DOI: https://doi.org/10.1016/j.bbagen.2015.05.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Quantitative Real-Time Quaking-Induced Conversion Allows Monitoring of Disease-Modifying Therapy in the Urine of Prion-Infected Mice​
    Shi, S.; Wagner, J. ; Mitteregger-Kretzschmar, G.; Ryazanov, S. ; Leonov, A. ; Griesinger, C.   & Giese, A.​ (2015) 
    Journal of Neuropathology and Experimental Neurology, 74(9) pp. 924​-933​.​ DOI: https://doi.org/10.1097/NEN.0000000000000233 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​The oligomer modulator anle138b is effective in the prodromal phase of a transgenic mouse model of Parkinson's disease​
    Prix, C.; Schmidt, F.; Levin, J.; Schinke, K.; Shi, S.; Ryazanov, S.   & Leonov, A.  et al.​ (2014)
    ​European Journal of Neurology. ​Joint Congress of European Neurology​, Istanbul, Turkey.
    ​Details 
  • 2014 | Journal Article | Letter Note | 
    ​ ​The oligomer modulator anle138b inhibits disease progression in a Parkinson mouse model even with treatment started after disease onset​
    Levin, J.; Schmidt, F.; Boehm, C.; Prix, C.; Boetzel, K.; Ryazanov, S.   & Leonov, A.  et al.​ (2014) 
    Acta Neuropathologica, 127(5) pp. 779​-780​.​ DOI: https://doi.org/10.1007/s00401-014-1265-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease​
    Wagner, J. ; Ryazanov, S. ; Leonov, A. ; Levin, J.; Shi, S.; Schmidt, F. & Prix, C. et al.​ (2013) 
    Acta Neuropathologica, 125(6) pp. 795​-813​.​ DOI: https://doi.org/10.1007/s00401-013-1114-9 
    ​Details  DOI  PMID  PMC  WoS 

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