Prof. Dr. Kai Tittmann

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  • 2023 Journal Article | 
    ​ ​Mechanisms of Cysteine‐Lysine Covalent Linkage ‐ The Role of Reactive Oxygen Species and Competition with Disulfide Bonds​
    Ye, J.; Bazzi, S.; Fritz, T.; Tittmann, K. ; Mata, R. A.   & Uranga, J. ​ (2023) 
    Angewandte Chemie. International Edition, art. e202304163​.​ DOI: 
    Details  DOI 
  • 2023 Conference Abstract
    ​ ​Exopolyphosphatase Activity of PRUNE Regulates Adaptive Starvation Responses in Cancer Cells​
    Cinar, B.; von Pappenheim, F. R.; Schreek, S.; Khalida Ibrahim, N.; Loxha, L.; Niessen, J. & Stasche, A. S. et al.​ (2023)
    ​34. Jahrestagung der Kind-Philipp-Stiftung für pädiatrischonkologische Forschung​, Wilsede.
    Georg Thieme Verlag. DOI: 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Crossing the Border: From Keto‐ to Imine Reduction in Short‐Chain Dehydrogenases/Reductases​
    Roth, S.; Stockinger, P.; Steff, J.; Steimle, S.; Sautner, V.; Tittmann, K.   & Pleiss, J. et al.​ (2020) 
    ChemBioChem21(18) pp. 2615​-2619​.​ DOI: 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase​
    Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H. ; Tittmann, K.   & Stark, H.  et al.​ (2020) 
    Cell180(6) pp. 1130​-1143.e20​.​ DOI: 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Structural basis for antibiotic action of the B1 antivitamin 2′-methoxy-thiamine​
    Rabe von Pappenheim, F.; Aldeghi, M.; Shome, B.; Begley, T.; de Groot, B. L.   & Tittmann, K. ​ (2020) 
    Nature Chemical Biology16(11) pp. 1237​-1245​.​ DOI: 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Structural and Functional Analyses of the Human PDH Complex Suggest a “Division-of-Labor” Mechanism by Local E1 and E3 Clusters​
    Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C. & Stark, H.  et al.​ (2019) 
    Structure27(7) pp. 1124​-1136.e4​.​ DOI: 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Low-barrier hydrogen bonds in enzyme cooperativity​
    Dai, S.-B.; Funk, L. M. ; Rabe von Pappenheim, F.; Sautner, V.; Paulikat, M.; Schröder, B. & Uranga, J.  et al.​ (2019) 
    Nature573(7775) pp. 609​-613​.​ DOI: 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Theoretical Studies of the Electronic Absorption Spectra of Thiamin Diphosphate in Pyruvate Decarboxylase​
    Paulikat, M.; Wechsler, C.; Tittmann, K.   & Mata, R. A. ​ (2017) 
    Biochemistry56(13) pp. 1854​-1864​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article
    ​ ​The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design​
    Schrader, J.; Henneberg, F.; Mata, R. A. ; Tittmann, K. ; Schneider, T. R.; Stark, H.   & Bourenkov, G. P. et al.​ (2016) 
    Science353(6299) pp. 594​-598​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2016 Journal Article | 
    ​ ​PtdInsP(2) and PtdSer cooperate to trap synaptotagmin-1 to the plasma membrane in the presence of calcium​
    Perez-Lara, A.; Thapa, A.; Nyenhuis, S. B.; Nyenhuis, D. A.; Halder, P.; Tietzel, M. & Tittmann, K.  et al.​ (2016) 
    eLife5 art. e15886​.​ DOI: 
    Details  DOI  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding P-II-like Signal Transduction Protein DarA​
    Gundlach, J.; Dickmanns, A. ; Schröder-Tittmann, K. ; Neumann, P. ; Kaesler, J.; Kampf, J. & Herzberg, C. et al.​ (2015) 
    Journal of biological chemistry290(5) pp. 3069​-3080​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space​
    Chari, A.; Haselbach, D.; Kirves, J.-M.; Ohmer, J.; Paknia, E.; Fischer, N.   & Ganichkin, O. et al.​ (2015) 
    Nature Methods12(9) pp. 859​-865​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Converting Transaldolase into Aldolase through Swapping of the Multifunctional Acid-Base Catalyst: Common and Divergent Catalytic Principles in F6P Aldolase and Transaldolase​
    Sautner, V.; Friedrich, M. M.; Lehwess-Litzmann, A. & Tittmann, K. ​ (2015) 
    Biochemistry54(29) pp. 4475​-4486​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article | Research Paper
    ​ ​Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot​
    Wechsler, C.; Meyer, D.; Loschonsky, S.; Funk, L.-M. ; Neumann, P. ; Ficner, R.   & Brodhun, F.  et al.​ (2015) 
    ChemBioChem16(18) pp. 2580​-2584​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | Research Paper
    ​ ​Marvels of enzyme catalysis at true atomic resolution: distortions, bond elongations, hidden flips, protonation states and atom identities​
    Neumann, P.   & Tittmann, K. ​ (2014) 
    Current Opinion in Structural Biology29 pp. 122​-133​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Observation of a stable carbene at the active site of a thiamin enzyme​
    Meyer, D.; Neumann, P. ; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemical Biology9(8) pp. 488​-U84​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate​
    Lüdtke, S.; Neumann, P. ; Erixon, K. M.; Leeper, F.; Kluger, R.; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemistry5(9) pp. 762​-767​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | Research Paper
    ​ ​Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin​
    Meyer, D.; Neumann, P. ; Koers, E.; Sjuts, H.; Lüdtke, S.; Sheldrick, G. M.   & Ficner, R.  et al.​ (2012) 
    Proceedings of the National Academy of Sciences109(27) pp. 10867​-10872​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism​
    Lehwess-Litzmann, A.; Neumann, P. ; Parthier, C.; Luedtke, S.; Golbik, R.; Ficner, R.   & Tittmann, K. ​ (2011) 
    Nature Chemical Biology7(10) pp. 678​-684​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​The Crystal Structure of the C(2)A Domain of Otoferlin Reveals an Unconventional Top Loop Region​
    Helfmann, S.; Neumann, P. ; Tittmann, K. ; Moser, T. ; Ficner, R.   & Reisinger, E. ​ (2011) 
    Journal of Molecular Biology406(3) pp. 479​-490​.​ DOI: 
    Details  DOI  PMID  PMC  WoS 

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