Prof. Dr. Hauke Hillen

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  • 2022 Journal Article | Research Paper | 
    ​ ​WARS1 and SARS1: Two tRNA synthetases implicated in autosomal recessive microcephaly​
    Bögershausen, N.; Krawczyk, H. E.; Jamra, R. A.; Lin, S.; Yigit, G. ; Hüning, I. & Polo, A. M. et al.​ (2022) 
    Human Mutation43(10) pp. 1454​-1471​.​ DOI: https://doi.org/10.1002/humu.24430 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Overview | 
    ​ ​Mitochondrien: wie die Gene im Kraftwerk der Zelle aktiviert werden​
    Bhatta, A. & Hillen, H. S. ​ (2022) 
    Biospektrum28(1) pp. 18​-20​.​ DOI: https://doi.org/10.1007/s12268-022-1711-z 
    Details  DOI 
  • 2022 Journal Article | Overview | 
    ​ ​Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes​
    Bhatta, A. & Hillen, H. S. ​ (2022) 
    Trends in Biochemical Sciences47(11) pp. 965​-977​.​ DOI: https://doi.org/10.1016/j.tibs.2022.05.006 
    Details  DOI  PMID  PMC 
  • 2021 Preprint
    ​ ​Dimeric form of SARS-CoV-2 polymerase​
    Jochheim, F. A.; Tegunov, D.; Hillen, H. S. ; Schmitzova, J.; Kokic, G.; Dienemann, C.& Cramer, P. ​ (2021). DOI: https://doi.org/10.1101/2021.03.23.436644 
    Details  DOI 
  • 2021 Preprint
    ​ ​Structural basis of GTPase-mediated mitochondrial ribosome biogenesis and recycling​
    Hillen, H. S. ; Lavdovskaia, E.; Nadler, F.; Hanitsch, E.; Linden, A.; Bohnsack, K. E.& Urlaub, H. et al.​ (2021). DOI: https://doi.org/10.1101/2021.03.17.435767 
    Details  DOI 
  • 2021 Preprint
    ​ ​Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis​
    Kabinger, F.; Stiller, C.; Schmitzová, J.; Dienemann, C.; Hillen, H. S. ; Höbartner, C.& Cramer, P. ​ (2021). DOI: https://doi.org/10.1101/2021.05.11.443555 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Structural basis of RNA processing by human mitochondrial RNase P​
    Bhatta, A.; Dienemann, C. ; Cramer, P.   & Hillen, H. S. ​ (2021) 
    Nature Structural & Molecular Biology28(9) pp. 713​-723​.​ DOI: https://doi.org/10.1038/s41594-021-00637-y 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​The structure of a dimeric form of SARS-CoV-2 polymerase​
    Jochheim, F. A.; Tegunov, D. ; Hillen, H. S. ; Schmitzová, J.; Kokic, G. ; Dienemann, C.   & Cramer, P. ​ (2021) 
    Communications Biology4(1) art. 999​.​ DOI: https://doi.org/10.1038/s42003-021-02529-9 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis​
    Kabinger, F.; Stiller, C.; Schmitzová, J.; Dienemann, C. ; Kokic, G. ; Hillen, H. S.   & Höbartner, C.  et al.​ (2021) 
    Nature Structural & Molecular Biology,.​ DOI: https://doi.org/10.1038/s41594-021-00651-0 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Structure and function of SARS-CoV-2 polymerase​
    Hillen, H. S. ​ (2021) 
    Current Opinion in Virology48 pp. 82​-90​.​ DOI: https://doi.org/10.1016/j.coviro.2021.03.010 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3′-UTRs of yeast mitochondrial mRNAs​
    Hillen, H. S. ; Markov, D. A.; Wojtas, I. D.; Hofmann, K. B.; Lidschreiber, M.; Cowan, A. T. & Jones, J. L. et al.​ (2021) 
    Proceedings of the National Academy of Sciences118(15) pp. e2009329118​.​ DOI: https://doi.org/10.1073/pnas.2009329118 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Overview | 
    ​ ​Hierarchical folding of the catalytic core during mitochondrial ribosome biogenesis​
    Lavdovskaia, E.; Hillen, H. S.   & Richter-Dennerlein, R. ​ (2021) 
    Trends in Cell Biology,.​ DOI: https://doi.org/10.1016/j.tcb.2021.09.004 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Mechanism of SARS-CoV-2 polymerase stalling by remdesivir​
    Kokic, G. ; Hillen, H. S. ; Tegunov, D. ; Dienemann, C. ; Seitz, F.; Schmitzova, J. & Farnung, L. et al.​ (2021) 
    Nature Communications12(1) art. 279​.​ DOI: https://doi.org/10.1038/s41467-020-20542-0 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper
    ​ ​Small-molecule inhibitors of human mitochondrial DNA transcription​
    Bonekamp, N. A.; Peter, B.; Hillen, H. S. ; Felser, A.; Bergbrede, T.; Choidas, A. & Horn, M. et al.​ (2020) 
    Nature588(7839) pp. 712-716​-716​.​ DOI: https://doi.org/10.1038/s41586-020-03048-z 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Structure of replicating SARS-CoV-2 polymerase​
    Hillen, H. S. ; Kokic, G.; Farnung, L.; Dienemann, C.; Tegunov, D. & Cramer, P. ​ (2020) 
    Nature584(7819) pp. 154-156​-156​.​ DOI: https://doi.org/10.1038/s41586-020-2368-8 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Structural Basis of Poxvirus Transcription: Transcribing and Capping Vaccinia Complexes​
    Hillen, H. S. ; Bartuli, J.; Grimm, C.; Dienemann, C. ; Bedenk, K.; Szalay, A. A & Fischer, U. et al.​ (2019) 
    Cell179(7) pp. 1525​-1536​.​ DOI: https://doi.org/10.1016/j.cell.2019.11.023 
    Details  DOI  PMID  PMC 
  • 2019 Journal Article | Research Paper
    ​ ​Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes​
    Grimm, C.; Hillen, H. S. ; Bedenk, K.; Bartuli, J.; Neyer, S.; Zhang, Q. & Hüttenhofer, A. et al.​ (2019) 
    Cell179(7) pp. 1537​-1550​.​ DOI: https://doi.org/10.1016/j.cell.2019.11.024 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article
    ​ ​Structural basis of mitochondrial transcription​
    Hillen, H. S. ; Temiakov, D. & Cramer, P. ​ (2018) 
    Nature Structural & Molecular Biology25(9) pp. 754​-765​.​ DOI: https://doi.org/10.1038/s41594-018-0122-9 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Structural Basis of Mitochondrial Transcription Initiation​
    Hillen, H. S. ; Morozov, Y. I.; Sarfallah, A.; Temiakov, D. & Cramer, P. ​ (2017) 
    Cell171(5) pp. 1072​-1081​.​ DOI: https://doi.org/10.1016/j.cell.2017.10.036 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​Mechanism of Transcription Anti-termination in Human Mitochondria​
    Hillen, H. S. ; Parshin, A. V.; Agaronyan, K.; Morozov, Y. I.; Graber, J. J.; Chernev, A.   & Schwinghammer, K. et al.​ (2017) 
    Cell171(5) pp. 1082​-1093​.​ DOI: https://doi.org/10.1016/j.cell.2017.09.035 
    Details  DOI  PMID  PMC 

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