Niklas Joisten

 
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  • 2024 Journal Article | 
    ​ ​Impact of exercise on markers of B cell-related immunity: A systematic review​
    Walzik, D.; Belen, S.; Wilisch, K.; Kupjetz, M.; Kirschke, S.; Esser, T. & Joisten, N.  et al.​ (2024) 
    Journal of sport and health science13(3) pp. 339​-352​.​ DOI: https://doi.org/10.1016/j.jshs.2023.10.002 
    Details  DOI  PMID  PMC 
  • 2024 Journal Article | 
    ​ ​Molecular insights of exercise therapy in disease prevention and treatment​
    Walzik, D.; Wences Chirino, T. Y.; Zimmer, P. & Joisten, N. ​ (2024) 
    Signal Transduction and Targeted Therapy9(1).​ DOI: https://doi.org/10.1038/s41392-024-01841-0 
    Details  DOI 
  • 2024 Preprint | 
    ​ ​Acute exercise increases systemic kynurenine pathway metabolites and activates the AHR in human PBMCs​
    Joisten, N. ; Walzik, D.; Schenk, A.; Metcalfe, A. J.; Belen, S.; Schaaf, K.& Gehlert, S. et al.​ (2024). DOI: https://doi.org/10.1101/2024.01.17.576018 10.1101/2024.01.17.576018 
    Details  DOI; DOI 
  • 2024 Journal Article
    ​ ​Kinetics of immune cell mobilization during acute aerobic exercise in healthy adults​
    Adammek, F.; Wences, T.; Walzik, D.; Trebing, S.; Belen, S.; Renpening, D. & Zimmer, P. et al.​ (2024) 
    International Journal of Sports Medicine,.​ DOI: https://doi.org/10.1055/a-2338-5397 10.1055/a-2338-5397 
    Details  DOI; DOI  PMID  PMC 
  • 2023 Journal Article
    ​ ​Physical activity is related to disease severity and fatigue, but not to relapse rate in persons with relapsing remitting multiple sclerosis - a self-reported questionnaire based study​
    Schlagheck, M. L.; Hübner, S. T.; Joisten, N. ; Walzik, D.; Rademacher, A.; Wolf, F. & Bansi, J. et al.​ (2023) 
    Frontiers in Neurology14 pp. 1217000​.​ DOI: https://doi.org/10.3389/fneur.2023.1217000 
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  • 2023 Journal Article | 
    ​ ​Effects of inpatient energy management education and high-intensity interval training on health-related quality of life in persons with multiple sclerosis: A randomized controlled superiority trial with six-month follow-up​
    Patt, N.; Kupjetz, M.; Kool, J.; Hersche, R.; Oberste, M.; Joisten, N.   & Gonzenbach, R. et al.​ (2023) 
    Multiple Sclerosis and Related Disorders78 pp. 104929​.​ DOI: https://doi.org/10.1016/j.msard.2023.104929 
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  • 2023 Journal Article
    ​ ​Older adults with cytomegalovirus reveal increased CD8+/CD4+EMRA T cells and elevated systemic levels of kynurenic acid​
    Joisten, N. ; Chirino, T. Y. W.; Boßlau, T. K.; Wasserfurth, P.; Hahn, A.; Krüger, K. & Zimmer, P.​ (2023) 
    Immunology169(1) pp. 113​-116​.​ DOI: https://doi.org/10.1111/imm.13609 
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  • 2023 Journal Article | 
    ​ ​12-week combined strength and endurance exercise attenuates CD8+ T-cell differentiation and affects the kynurenine pathway in the elderly: a randomized controlled trial​
    Boßlau, T. K.; Wasserfurth, P.; Reichel, T.; Weyh, C.; Palmowski, J.; Nebl, J. & Joisten, N.  et al.​ (2023) 
    Immunity & Ageing20(1) pp. 19​.​ DOI: https://doi.org/10.1186/s12979-023-00347-7 
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  • 2023 Journal Article | 
    ​ ​Cycling in primary progressive multiple sclerosis (CYPRO): study protocol for a randomized controlled superiority trial evaluating the effects of high-intensity interval training in persons with primary progressive multiple sclerosis​
    Kupjetz, M.; Joisten, N. ; Rademacher, A.; Gonzenbach, R.; Bansi, J. & Zimmer, P.​ (2023) 
    BMC Neurology23(1) pp. 162​.​ DOI: https://doi.org/10.1186/s12883-023-03187-6 
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  • 2023 Journal Article | 
    ​ ​Tissue‐specific effects of exercise as NAD+‐boosting strategy: Current knowledge and future perspectives​
    Walzik, D.; Jonas, W.; Joisten, N. ; Belen, S.; Wüst, R. C. I.; Guillemin, G. & Zimmer, P.​ (2023) 
    Acta Physiologica237(3) pp. e13921​.​ DOI: https://doi.org/10.1111/apha.13921 
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  • 2023 Journal Article
    ​ ​The serum kynurenine pathway metabolic profile is associated with overweight and obesity in multiple sclerosis​
    Kupjetz, M.; Patt, N.; Joisten, N. ; Ueland, P. M.; McCann, A.; Gonzenbach, R. & Bansi, J. et al.​ (2023) 
    Multiple Sclerosis and Related Disorders72 pp. 104592​.​ DOI: https://doi.org/10.1016/j.msard.2023.104592 
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  • 2022 Preprint
    ​ ​Acute exercise induces natural killer cell mobilization but not infiltration into prostate cancer tissue in humans​
    Schenk, A.; Esser, T.; Belen, S.; Gunasekara, N.; Joisten, N. ; Winker, M.& Weike, L. et al.​ (2022). DOI: https://doi.org/10.1101/2022.04.28.22274307 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Distinct distribution patterns of exercise-induced natural killer cell mobilization into the circulation and tumor tissue of patients with prostate cancer​
    Joisten, N. ​ (2022) 
    American Journal of Physiology. Cell physiology323(3) pp. C879​-C884​.​ DOI: https://doi.org/10.1152/ajpcell.00243.2022 
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  • 2022 Journal Article
    ​ ​Effect of sleep and fatigue on cardiovascular performance in young, healthy subjects​
    Castelli, L.; Walzik, D.; Joisten, N. ; Watson, M.; Montaruli, A.; Oberste, M. & Roveda, E. et al.​ (2022) 
    Physiology & Behavior256 pp. 113963​.​ DOI: https://doi.org/10.1016/j.physbeh.2022.113963 
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  • 2022 Journal Article
    ​ ​L-kynurenine as a prognostic marker for early mortality in patients with acute myeloid leukemia​
    Kierdorf, F.; Zimmer, P.; Joisten, N. ; Kiesl, D.; Winker, M.; Rigoux, L. & Elter, T.​ (2022) 
    Leukemia & Lymphoma63(8) pp. 2001​-2004​.​ DOI: https://doi.org/10.1080/10428194.2022.2053534 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | 
    ​ ​Cellular Integrative Immune Markers in Elite Athletes​
    Zacher, J.; Wesemann, F.; Joisten, N. ; Walzik, D.; Bloch, W. & Predel, G.​ (2022) 
    International Journal of Sports Medicine44(4) pp. 298​-308​.​ DOI: https://doi.org/10.1055/a-1976-6069 
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  • 2022 Journal Article
    ​ ​Fitness, physical activity, and exercise in multiple sclerosis: a systematic review on current evidence for interactions with disease activity and progression​
    Proschinger, S.; Kuhwand, P.; Rademacher, A.; Walzik, D.; Warnke, C.; Zimmer, P. & Joisten, N. ​ (2022) 
    Journal of Neurology269(6) pp. 2922​-2940​.​ DOI: https://doi.org/10.1007/s00415-021-10935-6 
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  • 2021 Journal Article
    ​ ​Impact of induction chemotherapy on objective and self-perceived cognitive performance in patients suffering from hematological disorders​
    Joisten, N. ​ (2021) 
    Leukemia & Lymphoma62(10) pp. 2526​-2530​.​ DOI: https://doi.org/10.1080/10428194.2021.1913151 10.1080/10428194.2021.1913151 
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  • 2021 Journal Article
    ​ ​The effect of exercise on regulatory T cells: A systematic review of human and animal studies with future perspectives and methodological recommendations​
    Joisten, N. ​ (2021) 
    Exercise immunology review27 pp. 142​-166​.​
    Details  PMID  PMC 
  • 2021 Journal Article | 
    ​ ​Exercise Diminishes Plasma Neurofilament Light Chain and Reroutes the Kynurenine Pathway in Multiple Sclerosis​
    Joisten, N. ​ (2021) 
    Neurology: Neuroimmunology & Neuroinflammation8(3).​ DOI: https://doi.org/10.1212/nxi.0000000000000982 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | 
    ​ ​Systematic Review of Exercise Studies in Persons with Multiple Sclerosis: Exploring the Quality of Interventions According to the Principles of Exercise Training​
    Joisten, N. ​ (2021) 
    Neurology and Therapy10(2) pp. 585​-607​.​ DOI: https://doi.org/10.1007/s40120-021-00274-z 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | 
    ​ ​Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8+ EMRA Cells in the Elderly​
    Joisten, N. ​ (2021) 
    Cells10(5).​ DOI: https://doi.org/10.3390/cells10050998 
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  • 2021 Journal Article
    ​ ​Feasibility and suitability of a graded exercise test in patients with aggressive hemato-oncological disease​
    Joisten, N. ​ (2021) 
    Supportive Care in Cancer29(8) pp. 4859​-4866​.​ DOI: https://doi.org/10.1007/s00520-021-06035-w 
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  • 2021 Journal Article
    ​ ​The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?​
    Joisten, N. ​ (2021) 
    Trends in Molecular Medicine27(10) pp. 946​-954​.​ DOI: https://doi.org/10.1016/j.molmed.2021.07.006 
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  • 2021 Journal Article
    ​ ​Exercise reduces systemic immune inflammation index (SII) in childhood cancer patients​
    Winker, M.; Stössel, S.; Neu, M. A.; Lehmann, N.; El Malki, K.; Paret, C. & Joisten, N.  et al.​ (2021) 
    Supportive Care in Cancer30(4) pp. 2905​-2908​.​ DOI: https://doi.org/10.1007/s00520-021-06719-3 
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  • 2021 Journal Article | 
    ​ ​Sleep problems and their interaction with physical activity and fatigue in hematological cancer patients during onset of high dose chemotherapy​
    Joisten, N. ​ (2021) 
    Supportive Care in Cancer30(1) pp. 167​-176​.​ DOI: https://doi.org/10.1007/s00520-021-06377-5 
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  • 2021 Journal Article | 
    ​ ​High-intensity interval training and energy management education, compared with moderate continuous training and progressive muscle relaxation, for improving health-related quality of life in persons with multiple sclerosis: study protocol of a randomized controlled superiority trial with six months' follow-up​
    Joisten, N. ​ (2021) 
    BMC Neurology21(1) pp. 65​.​ DOI: https://doi.org/10.1186/s12883-021-02084-0 
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  • 2021 Journal Article | 
    ​ ​Transferring clinically established immune inflammation markers into exercise physiology: focus on neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio and systemic immune-inflammation index​
    Joisten, N. ​ (2021) 
    European Journal of Applied Physiology121(7) pp. 1803​-1814​.​ DOI: https://doi.org/10.1007/s00421-021-04668-7 
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  • 2021 Journal Article
    ​ ​Acute aerobic exercise to recover from mental exhaustion - a randomized controlled trial​
    Joisten, N. ​ (2021) 
    Physiology & Behavior241 pp. 113588​.​ DOI: https://doi.org/10.1016/j.physbeh.2021.113588 10.1016/j.physbeh.2021.113588 
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  • 2021 Journal Article
    ​ ​The aerobic capacity - fatigue relationship in persons with Multiple Sclerosis is not reproducible in a pooled analysis of two randomized controlled trials​
    Wolf, F.; Rademacher, A.; Joisten, N. ; Proschinger, S.; Schlagheck, M. L.; Bloch, W. & Gonzenbach, R. et al.​ (2021) 
    Multiple Sclerosis and Related Disorders58 pp. 103476​.​ DOI: https://doi.org/10.1016/j.msard.2021.103476 
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  • 2021 Journal Article
    ​ ​VO2peak Response Heterogeneity in Persons with Multiple Sclerosis: To HIIT or Not to HIIT?​
    Joisten, N. ​ (2021) 
    International Journal of Sports Medicine42(14) pp. 1319​-1328​.​ DOI: https://doi.org/10.1055/a-1481-8639 10.1055/a-1481-8639 
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  • 2021 Journal Article
    ​ ​Do baseline cognitive status, participant specific characteristics and EDSS impact changes of cognitive performance following aerobic exercise intervention in multiple sclerosis?​
    Joisten, N. ​ (2021) 
    Multiple Sclerosis and Related Disorders51 pp. 102905​.​ DOI: https://doi.org/10.1016/j.msard.2021.102905 10.1016/j.msard.2021.102905 
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  • 2021 Journal Article
    ​ ​Is high-intensity interval training harmful to health?​
    Joisten, N. ​ (2021) 
    Trends in Endocrinology and Metabolism33(2) pp. 85​-86​.​ DOI: https://doi.org/10.1016/j.tem.2021.07.003 10.1016/j.tem.2021.07.003 
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  • 2021 Journal Article
    ​ ​How acute physical and psychological stress differentially influence the kynurenine pathway: A randomized cross-over trial​
    Herhaus, B.; Joisten, N. ; Wessels, I.; Zimmer, P. & Petrowski, K.​ (2021) 
    Psychoneuroendocrinology134 pp. 105433​.​ DOI: https://doi.org/10.1016/j.psyneuen.2021.105433 
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  • 2020 Journal Article
    ​ ​Trainuvimab: Impact Of High-intensity Exercise On Cognition In Multiple Sclerosis - Interim And Subgroup Analysis​
    Rademacher, A.; Bansi, J.; Joisten, N. ; Proschinger, S.; Schlagheck, M. L.; Bloch, W. & Oberste, M. et al.​ (2020) 
    Medicine and Science in Sports and Exercise52(7S).​ DOI: https://doi.org/10.1249/01.mss.0000680840.34382.9a 
    Details  DOI 
  • 2020 Journal Article
    ​ ​High-intensity Interval Training Reduces Symptom- And Disability-associated Inflammation Marker In Persons With Multiple Sclerosis​
    Joisten, N. ; Bansi, J.; Rademacher, A.; Proschinger, S.; Schenk, A.; Bloch, W. & Zimmer, P.​ (2020) 
    Medicine and Science in Sports and Exercise52(7S).​ DOI: https://doi.org/10.1249/01.mss.0000671592.48065.ce 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Influence Of High-intensity Interval Training On Fatigue, Depression And Anxiety In People With Multiple Sclerosis​
    Schlagheck, M. L.; Joisten, N. ; Rademacher, A.; Proschinger, S.; Oberste, M.; Schenk, A. & Kool, J. et al.​ (2020) 
    Medicine and Science in Sports and Exercise52(7S).​ DOI: https://doi.org/10.1249/01.mss.0000671584.92229.2f 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Exercise and the Kynurenine pathway: Current state of knowledge and results from a randomized cross-over study comparing acute effects of endurance and resistance training​
    Joisten, N. ​ (2020) 
    Exercise immunology review26 pp. 24​-42​.​
    Details  PMID  PMC 
  • 2020 Journal Article
    ​ ​Influence Of High-intensity Training On Quality Of Life And Daily Activity Performance In Multiple Sclerosis​
    Proschinger, S.; Bansi, J.; Rademacher, A.; Joisten, N. ; Schenk, A.; Oberste, M. & Kool, J. et al.​ (2020) 
    Medicine and Science in Sports and Exercise52(7S) pp. 138​-139​.​ DOI: https://doi.org/10.1249/01.mss.0000671608.39972.68 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​Physical Activity for the Treatment of Adolescent Depression: A Systematic Review and Meta-Analysis​
    Oberste, M.; Medele, M.; Javelle, F.; Wunram, H. L.; Walter, D.; Bloch, W. & Bender, S. et al.​ (2020) 
    Frontiers in Physiology11 pp. 185​.​ DOI: https://doi.org/10.3389/fphys.2020.00185 
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  • 2020 Journal Article | 
    ​ ​Cognitive Impairment Impacts Exercise Effects on Cognition in Multiple Sclerosis​
    Joisten, N. ​ (2020) 
    Frontiers in Neurology11 pp. 619500​.​ DOI: https://doi.org/10.3389/fneur.2020.619500 
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  • 2020 Journal Article | 
    ​ ​Effect of a Single Bout of Aerobic Exercise on Kynurenine Pathway Metabolites and Inflammatory Markers in Prostate Cancer Patients-A Pilot Randomized Controlled Trial​
    Joisten, N. ​ (2020) 
    Metabolites11(1).​ DOI: https://doi.org/10.3390/metabo11010004 
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  • 2020 Journal Article | 
    ​ ​Cellular immune response to acute exercise: Comparison of endurance and resistance exercise​
    Schlagheck, M. L.; Walzik, D.; Joisten, N. ; Koliamitra, C.; Hardt, L.; Metcalfe, A. J. & Wahl, P. et al.​ (2020) 
    European Journal Of Haematology105(1) pp. 75​-84​.​ DOI: https://doi.org/10.1111/ejh.13412 
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  • 2020 Journal Article | 
    ​ ​Physical Exercise as Kynurenine Pathway Modulator in Chronic Diseases: Implications for Immune and Energy Homeostasis​
    Joisten, N. ​ (2020) 
    International journal of tryptophan research13 pp. 1178646920938688​.​ DOI: https://doi.org/10.1177/1178646920938688 
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  • 2020 Journal Article
    ​ ​Acute hypertrophic but not maximal strength loading transiently enhances the kynurenine pathway towards kynurenic acid​
    Joisten, N. ; Schumann, M.; Schenk, A.; Walzik, D.; Freitag, N.; Knoop, A. & Thevis, M. et al.​ (2020) 
    European Journal of Applied Physiology120(6) pp. 1429​-1436​.​ DOI: https://doi.org/10.1007/s00421-020-04375-9 
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  • 2020 Journal Article
    ​ ​High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation​
    Joisten, N. ; Proschinger, S.; Rademacher, A.; Schenk, A.; Bloch, W.; Warnke, C. & Gonzenbach, R. et al.​ (2020) 
    Multiple Sclerosis Journal27(7) pp. 1136​-1139​.​ DOI: https://doi.org/10.1177/1352458520951382 
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  • 2020 Journal Article
    ​ ​Talking About Physical "Activity" or "Inactivity"? The Need of Accurate Activity Controlling in Exercise Studies in Rodents​
    Joisten, N. ​ (2020) 
    Frontiers in Physiology11 pp. 611193​.​ DOI: https://doi.org/10.3389/fphys.2020.611193 
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  • 2019 Journal Article
    ​ ​Do Acute Exercise-Induced Activations of the Kynurenine Pathway Induce Regulatory T-Cells on the Long-Term? - A Theoretical Frame Work Supported by Pilot Data​
    Koliamitra, C.; Javelle, F.; Joisten, N. ; Shimabukuro-Vornhagen, A.; Bloch, W.; Schenk, A. & Zimmer, P.​ (2019) 
    Journal of Sports Science & Medicine18(4) pp. 669​-673​.​
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  • 2019 Journal Article
    ​ ​Exercise-neuroimmunology – from bench to bedside​
    Zimmer, P.; Bansi, J.; Rademacher, A.; Schlagheck, M. L.; Walzik, D.; Proschinger, S. & Bloch, W. et al.​ (2019) 
    Deutsche Zeitschrift für Sportmedizin,.​ DOI: https://doi.org/10.5960/dzsm.2019.392 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Impact of physical exercise on the kynurenine pathway in patients with cancer: current limitations and future perspectives​
    Zimmer, P.; Joisten, N. ; Schenk, A. & Bloch, W.​ (2019) 
    Acta Oncologica58(8).​ DOI: https://doi.org/10.1080/0284186x.2019.1599139 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Influence of combined functional resistance and endurance exercise over 12 weeks on matrix metalloproteinase-2 serum concentration in persons with relapsing-remitting multiple sclerosis – a community-based randomized controlled trial​
    Proschinger, S.; Joisten, N. ; Rademacher, A.; Schlagheck, M. L.; Walzik, D.; Metcalfe, A. J. & Oberste, M. et al.​ (2019) 
    BMC Neurology19(1) pp. 314​.​ DOI: https://doi.org/10.1186/s12883-019-1544-7 
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  • 2019 Journal Article | 
    ​ ​Effects and Moderators of Acute Aerobic Exercise on Subsequent Interference Control: A Systematic Review and Meta-Analysis​
    Oberste, M.; Javelle, F.; Sharma, S.; Joisten, N. ; Walzik, D.; Bloch, W. & Zimmer, P.​ (2019) 
    Frontiers in Psychology10 pp. 2616​.​ DOI: https://doi.org/10.3389/fpsyg.2019.02616 
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  • 2019 Journal Article | 
    ​ ​Influence of different rehabilitative aerobic exercise programs on (anti-) inflammatory immune signalling, cognitive and functional capacity in persons with MS – study protocol of a randomized controlled trial​
    Joisten, N. ; Rademacher, A.; Bloch, W.; Schenk, A.; Oberste, M.; Dalgas, U. & Langdon, D. et al.​ (2019) 
    BMC Neurology19(1) pp. 37​.​ DOI: https://doi.org/10.1186/s12883-019-1267-9 
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  • 2019 Journal Article
    ​ ​Aqua cycling for immunological recovery after intensive, eccentric exercise​
    Joisten, N. ; Walzik, D.; Schenk, A.; Bloch, W.; Zimmer, P. & Wahl, P.​ (2019) 
    European Journal of Applied Physiology119(6) pp. 1369​-1375​.​ DOI: https://doi.org/10.1007/s00421-019-04127-4 
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  • 2018 Journal Article | 
    ​ ​Protocol for the “Chemobrain in Motion – study” (CIM – study): a randomized placebo-controlled trial of the impact of a high-intensity interval endurance training on cancer related cognitive impairments in women with breast cancer receiving first-line chemotherapy​
    Oberste, M.; Schaffrath, N.; Schmidt, K.; Bloch, W.; Jäger, E.; Steindorf, K. & Hartig, P. et al.​ (2018) 
    BMC Cancer18(1) pp. 1071​.​ DOI: https://doi.org/10.1186/s12885-018-4992-3 
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  • 2018 Journal Article
    ​ ​Persons with secondary progressive and relapsing remitting multiple sclerosis reveal different responses of tryptophan metabolism to acute endurance exercise and training​
    Bansi, J.; Koliamitra, C.; Bloch, W.; Joisten, N. ; Schenk, A.; Watson, M. & Kool, J. et al.​ (2018) 
    Journal of Neuroimmunology314 pp. 101​-105​.​ DOI: https://doi.org/10.1016/j.jneuroim.2017.12.001 
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  • 2017 Journal Article | 
    ​ ​Influence of Personalized Exercise Recommendations During Rehabilitation on the Sustainability of Objectively Measured Physical Activity Levels, Fatigue, and Fatigue-Related Biomarkers in Patients With Breast Cancer​
    Zimmer, P.; Baumann, F. T.; Oberste, M.; Schmitt, J.; Joisten, N. ; Hartig, P. & Schenk, A. et al.​ (2017) 
    Integrative cancer therapies17(2) pp. 306​-311​.​ DOI: https://doi.org/10.1177/1534735417713301 
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  • 2016 Journal Article
    ​ ​Impact of aerobic exercise training during chemotherapy on cancer related cognitive impairments in patients suffering from acute myeloid leukemia or myelodysplastic syndrome — Study protocol of a randomized placebo-controlled trial​
    Zimmer, P.; Oberste, M.; Bloch, W.; Schenk, A.; Joisten, N. ; Hartig, P. & Wolf, F. et al.​ (2016) 
    Contemporary Clinical Trials49 pp. 1​-5​.​ DOI: https://doi.org/10.1016/j.cct.2016.05.007 
    Details  DOI  PMID  PMC 

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