Dr. med. Thomas Horst Fischer

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  • 2022 | Journal Article | Research Paper
    ​ ​Herzinsuffizienz​
    Herting, J.; Fischer, T. H.   & Maack, C.​ (2022) 
    Der Nephrologe, 17(3) pp. 197​-207​.​ DOI: https://doi.org/10.1007/s11560-022-00575-w 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​
    Eiringhaus, J. ; Wünsche, C. M.; Tirilomis, P.; Herting, J. ; Bork, N.; Nikolaev, V. O.   & Hasenfuss, G.  et al.​ (2020) 
    ESC Heart Failure, 7(5) pp. 2992​-3002​.​ DOI: https://doi.org/10.1002/ehf2.12918 
    ​Details  DOI  PMID  PMC 
  • 2019 | Conference Paper
    ​ ​P3829 Antiarrhythmic effects of Sacubitrilat (LBQ657) on Ca2+ homeostasis in ventricular cardiomyocytes​
    Eiringhaus, J.; Wuensche, C.; Herting, J.; Hasenfuss, G. ; Sossalla, S.   & Fischer, T. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz745.0671 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper
    ​ ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​
    Eiringhaus, J. ; Herting, J. ; Schatter, F. ; Nikolaev, V. O. ; Sprenger, J.; Wang, Y. & Köhn, M. et al.​ (2019) 
    Basic Research in Cardiology, 114(2) pp. 13​.​ DOI: https://doi.org/10.1007/s00395-019-0720-7 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​
    Bergau, L.; Willems, R.; Sprenkeler, D. J; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    Data in Brief, 21 pp. 2110​-2116​.​ DOI: https://doi.org/10.1016/j.dib.2018.11.025 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Empagliflozin directly improves diastolic function in human heart failure​
    Pabel, S. ; Wagner, S. ; Bollenberg, H.; Bengel, P. ; Kovács, Á.; Schach, C. & Tirilomis, P. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1690​-1700​.​ DOI: https://doi.org/10.1002/ejhf.1328 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​
    Iyer, L. M ; Nagarajan, S. ; Woelfer, M.; Schoger, E.; Khadjeh, S. ; Zafiriou, M. P.   & Kari, V.  et al.​ (2018) 
    Nucleic Acids Research, 46(6) pp. 2850​-2867​.​ DOI: https://doi.org/10.1093/nar/gky049 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research, 114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​
    Bergau, L.; Willems, R.; Sprenkeler, D. J.; Fischer, T. H. ; Flevari, P.; Hasenfuß, G.   & Katsaras, D. et al.​ (2018) 
    International Journal of Cardiology, 272 pp. 102​-107​.​ DOI: https://doi.org/10.1016/j.ijcard.2018.06.103 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​PP1 activation as novel antiarrhythmic approach in human heart failure​
    Eiringhaus, J. ; Fischer, T. H. ; Kohn, M.; Wang, Y.; Maier, L. S. ; Hasenfuss, G.   & Sossalla, S. T. ​ (2017) 
    European Heart Journal, 38(suppl_1) art. P5841​.​ DOI: https://doi.org/10.1093/eurheartj/ehx493.P5841 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Serial assessment of left atrial deformation in patients undergoing pulmonary vein isolation: a cardiovascular magnetic resonance feasibility study​
    Bergau, L. ; Tichelbaecker, T. ; Kowallick, J. T. ; Lüthje, L. ; Fischer, T. H. ; Unterberg-Buchwald, C.   & Lotz, J.  et al.​ (2016) 
    Journal of Cardiovascular Magnetic Resonance, 18(Suppl 1) art. P362​.​ DOI: https://doi.org/10.1186/1532-429x-18-s1-p362 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET​
    Sprenger, J. U.; Bork, N. I.; Herting, J. ; Fischer, T. H.   & Nikolaev, V. O. ​ (2016) 
    PLoS One, 11(12) art. e0167974​.​ DOI: https://doi.org/10.1371/journal.pone.0167974 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​
    Hartmann, N. H. ; Mason, F. E. ; Braun, I.; Pabel, S. ; Voigt, N. ; Schotola, H. & Fischer, T. H.  et al.​ (2016) 
    Journal of Molecular and Cellular Cardiology, 94 pp. 95​-106​.​ DOI: https://doi.org/10.1016/j.yjmcc.2016.03.012 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Prediction of Appropriate Shocks Using 24-Hour Holter Variables and T-Wave Alternans After First Implantable Cardioverter-Defibrillator Implantation in Patients With Ischemic or Nonischemic Cardiomyopathy​
    Seegers, J.; Bergau, L. ; Exposito, P. M.; Bauer, A.; Fischer, T. H. ; Luethje, L.   & Hasenfuß, G.  et al.​ (2016) 
    The American Journal of Cardiology, 118(1) pp. 86​-94​.​ DOI: https://doi.org/10.1016/j.amjcard.2016.04.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​
    Fischer, T. H. ; Herting, J. ; Eiringhaus, J. ; Pabel, S. ; Hartmann, N. H. ; Ellenberger, D.   & Friedrich, M.  et al.​ (2016) 
    EP Europace, 18(9) pp. 1440​-1448​.​ DOI: https://doi.org/10.1093/europace/euv313 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure​
    Fischer, T. H. ; Kleinwächter, A.; Herting, J. ; Eiringhaus, J. ; Hartmann, N. ; Renner, A. & Gummert, J. et al.​ (2016) 
    Artificial Organs, 40(8) pp. 719​-726​.​ DOI: https://doi.org/10.1111/aor.12677 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators​
    Seegers, J.; Conen, D.; Jung, K. ; Bergau, L. ; Dorenkamp, M.; Luethje, L.   & Sohns, C. et al.​ (2016) 
    EP Europace, 18(8) pp. 1194​-1202​.​ DOI: https://doi.org/10.1093/europace/euv361 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​The combined effects of ranolazine and low dose dronedarone on atrial vs. ventricular electrophysiology; a novel therapeutic hope?​
    Hartmann, N.; Mason, F.; Braun, I.; Voigt, N. ; Fischer, T. H. ; Hasenfuß, G.   & Sossalla, S. T. ​ (2015)
    European Heart Journal, 36 pp. 1067​-1068. , London, ENGLAND.
    Oxford​: Oxford Univ Press.
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​
    Fischer, T. H. ; Herting, J. ; Mason, F. E. ; Hartmann, N. ; Watanabe, S.; Nikolaev, V. O.   & Sprenger, J. U. et al.​ (2015) 
    Cardiovascular Research, 107(1) pp. 184​-196​.​ DOI: https://doi.org/10.1093/cvr/cvv153 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure, 16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​
    Sag, C. M.; Mallwitz, A.; Wagner, S. ; Hartmann, N. ; Schotola, H.; Fischer, T. H.   & Ungeheuer, N. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology, 76 pp. 94​-105​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.08.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​
    Fischer, T. H. ; Neef, S. & Maier, L. S. ​ (2013) 
    Journal of Molecular and Cellular Cardiology, 58 pp. 182​-187​.​ DOI: https://doi.org/10.1016/j.yjmcc.2012.11.003 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​
    Toischer, K. ; Hartmann, N. ; Wagner, S. ; Fischer, T. H. ; Herting, J. ; Danner, B. C.   & Sag, C. M. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 61 pp. 111​-122​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.03.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​
    Fischer, T. H. ; Herting, J. ; Tirilomis, T. ; Renner, A.; Neef, S.; Toischer, K.   & Ellenberger, D.  et al.​ (2013) 
    Circulation, 128(9) pp. 970​-981​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.113.001746 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​
    Fischer, T. H. ; Maier, L. S.   & Sossalla, S. T. ​ (2013) 
    Heart Failure Reviews, 18(4) pp. 475​-483​.​ DOI: https://doi.org/10.1007/s10741-012-9339-6 
    ​Details  DOI  PMID  PMC  WoS 

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