Prof. Dr. med. Hans-Ulrich Schildhaus

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  • 2021 | Journal Article
    ​ ​Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition​
    Kemper, M.; Evers, G.; Schulze, A. B.; Sperveslage, J.; Schülke, C.; Lenz, G. & Herold, T. et al.​ (2021) 
    Oncotarget, 12(19) pp. 1946​-1952​.​ DOI: https://doi.org/10.18632/oncotarget.28062 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​An unusual lymphoid lesion mimicking meningioma​
    Abboud, T. ; Stork, L.; Schildhaus, H. ; Stadelmann, C. ; Rohde, V.   & Mielke, D. ​ (2021) 
    Brain Pathology, 31(5).​ DOI: https://doi.org/10.1111/bpa.12995 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Statistical modelling of HER2-positivity in breast cancer: Final analyses from two large, multicentre, non-interventional studies in Germany​
    Rüschoff, J. ; Lebeau, A.; Sinn, P.; Schildhaus, H.-U. ; Decker, T.; Ammann, J. & Künzel, C. et al.​ (2020) 
    The Breast, 49 pp. 246​-253​.​ DOI: https://doi.org/10.1016/j.breast.2019.12.005 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​A noninterventional, multinational study to assess PD‐L1 expression in cytological and histological lung cancer specimens​
    Bubendorf, L.; Conde, E.; Cappuzzo, F.; Langfort, R.; Schildhaus, H. ; Votruba, J. & Concha‐López, Á. et al.​ (2020) 
    Cancer Cytopathology, 128(12) pp. 928​-938​.​ DOI: https://doi.org/10.1002/cncy.22324 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer​
    Elakad, O.; Lois, A.; Schmitz, K.; Yao, S.; Hugo, S.; Lukat, L. & Hinterthaner, M.  et al.​ (2020) 
    Cancer Medicine, 9(10) pp. 3574​-3583​.​ DOI: https://doi.org/10.1002/cam4.2994 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis​
    Overbeck, T. R.; Cron, D. A.; Schmitz, K.; Rittmeyer, A.; Körber, W.; Hugo, S. & Schnalke, J. et al.​ (2020) 
    Translational Lung Cancer Research, 9(3) pp. 603​-616​.​ DOI: https://doi.org/10.21037/tlcr-19-339 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation​
    Bleckmann, A. ; Dierks, S.; Schildhaus, H.-U. ; Hellige, N.; Bacher, U. ; Trümper, L.   & Wulf, G. ​ (2020) 
    Annals of Hematology,.​ DOI: https://doi.org/10.1007/s00277-020-03974-y 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer​
    Jo, P. ; Bernhardt, M. ; Nietert, M. ; König, A. ; Azizian, A. ; Schirmer, M. A.   & Grade, M.  et al.​ (2020) 
    PLoS One, 15(10) pp. e0239806​.​ DOI: https://doi.org/10.1371/journal.pone.0239806 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Monitoring efficacy of checkpoint inhibitor therapy in patients with non-small-cell lung cancer​
    Schiwitza, A.; Schildhaus, H.-U. ; Zwerger, B.; Rüschoff, J. ; Reinhardt, C.; Leha, A.   & Andreas, S.  et al.​ (2019) 
    Immunotherapy, 11(9) pp. 769​-782​.​ DOI: https://doi.org/10.2217/imt-2019-0039 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial​
    Michels, S.; Massutí, B.; Schildhaus, H.-U. ; Franklin, J.; Sebastian, M.; Felip, E. & Grohé, C. et al.​ (2019) 
    Journal of Thoracic Oncology, 14(7) pp. 1266​-1276​.​ DOI: https://doi.org/10.1016/j.jtho.2019.03.020 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis​
    Pyczek, J. ; Khizanishvili, N.; Kuzyakova, M.; Zabel, S.; Bauer, J.; Nitzki, F. & Emmert, S.  et al.​ (2019) 
    Frontiers in Genetics, 10.​ DOI: https://doi.org/10.3389/fgene.2019.01185 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Automated density-based counting of FISH amplification signals for HER2 status assessment​
    Höfener, H.; Homeyer, A.; Förster, M.; Drieschner, N.; Schildhaus, H.-U.   & Hahn, H. K.​ (2019) 
    Computer Methods and Programs in Biomedicine, 173 pp. 77​-85​.​ DOI: https://doi.org/10.1016/j.cmpb.2019.03.006 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors — TORC1/2 Inhibition as Salvage Strategy​
    Mühlenberg, T.; Ketzer, J.; Heinrich, M. C.; Grunewald, S.; Marino-Enriquez, A.; Trautmann, M. & Hartmann, W. et al.​ (2019) 
    Molecular Cancer Therapeutics, 18(11) pp. 1985​-1996​.​ DOI: https://doi.org/10.1158/1535-7163.MCT-18-1224 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Loss of RNF40 Decreases NF-B Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice​
    Kosinsky, R. L. ; Chua, R. L.; Qui, M.; Saul, D. ; Mehlich, D.; Ströbel, P.   & Schildhaus, H.-U.  et al.​ (2019) 
    Journal of Crohn's and Colitis, 13(3) pp. 362​-373​.​ DOI: https://doi.org/10.1093/ecco-jcc/jjy165 
    ​Details  DOI  PMID  PMC  WoS 
  • 2018 | Book Chapter
    ​ ​Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations​
    Wolff, A. ; Perera-Bel, J. ; Schildhaus, H.-U. ; Homayounfar, K. ; Schatlo, B. ; Bleckmann, A.  & Beißbarth, T. ​ (2018)
    In: German Medical Data Sciences: A Learning Healthcare System pp. 217​-221. 
    ​Details 
  • 2018 | Journal Article
    ​ ​Der prädiktive Wert der PD-L1-Diagnostik​
    Schildhaus, H.-U. ​ (2018) 
    Der Pathologe, 39(6) pp. 498​-519​.​ DOI: https://doi.org/10.1007/s00292-018-0507-x 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​FGFR3-Überexpression ist eine relevante Alteration in kolorektalen Karzinomen​
    Fromme, J. E. & Schildhaus, H.-U. ​ (2018) 
    Der Pathologe, 39(S2) pp. 189​-192​.​ DOI: https://doi.org/10.1007/s00292-018-0504-0 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Dramatic Response of a PD-L1–Positive Advanced Angiosarcoma of the Scalp to Pembrolizumab​
    Hamacher, R.; Kämpfe, D.; Reuter-Jessen, K. ; Pöttgen, C.; Podleska, L. E.; Farzaliyev, F. & Steinau, H.-U. et al.​ (2018) 
    JCO Precision Oncology,(2) pp. 1​-7​.​ DOI: https://doi.org/10.1200/PO.17.00107 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​CIC fusion-positive sarcoma of the spermatic cord​
    Bremmer, F. ; Fichtner, A.; Triefenbach, R.; Inniger, R.; Mayer, P.; Lukat, L. & Ströbel, P.  et al.​ (2018) 
    Virchows Archiv, 474(2) pp. 253​-257​.​ DOI: https://doi.org/10.1007/s00428-018-2471-5 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Optimization and validation of PD-L1 immunohistochemistry staining protocols using the antibody clone 28-8 on different staining platforms​
    Koppel, C.; Schwellenbach, H.; Zielinski, D.; Eckstein, S.; Martin-Ortega, M.; D’Arrigo, C. & Schildhaus, H.-U.  et al.​ (2018) 
    Modern Pathology, 31(11) pp. 1630​-1644​.​ DOI: https://doi.org/10.1038/s41379-018-0071-1 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas​
    Ragab, N.; Viehweger, F.; Bauer, J.; Geyer, N.; Yang, M.; Seils, A. & Belharazem, D. et al.​ (2018) 
    Frontiers in Pediatrics, 6.​ DOI: https://doi.org/10.3389/fped.2018.00378 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment​
    Ihle, M. A.; Huss, S.; Jeske, W.; Hartmann, W.; Merkelbach-Bruse, S.; Schildhaus, H.-U.   & Büttner, R. et al.​ (2018) 
    PLoS One, 13(2) pp. e0193048​.​ DOI: https://doi.org/10.1371/journal.pone.0193048 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination​
    Barrantes-Freer, A. ; Engel, A. S.; Rodríguez-Villagra, O. A.; Winkler, A. ; Bergmann, M.; Mawrin, C. & Kuempfel, T. et al.​ (2017) 
    Brain Pathology, 28(2) pp. 225​-233​.​ DOI: https://doi.org/10.1111/bpa.12496 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC – Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP ® )​
    Petersen, I.; Dietel, M.; Geilenkeuser, W. J.; Mireskandari, M.; Weichert, W.; Steiger, K. & Scheel, A. H. et al.​ (2017) 
    Pathology - Research and Practice, 213(12) pp. 1530​-1535​.​ DOI: https://doi.org/10.1016/j.prp.2017.09.021 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Interlaboratory-concordance of PD-L1 IHC for NSCLC.​
    Scheel, A. H.; Bänfer, G.; Baretton, G. B.; Dietel, M.; Diezko, R.; Henkel, T. & Heukamp, L. C. et al.​ (2017) 
    Journal of Clinical Oncology, 35(15_suppl) pp. e20508​-e20508​.​ DOI: https://doi.org/10.1200/JCO.2017.35.15_suppl.e20508 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer​
    Scheel, A. H; Baenfer, G.; Baretton, G.; Dietel, M.; Diezko, R.; Henkel, T. & Heukamp, L. C et al.​ (2017) 
    Histopathology, 72(3) pp. 449​-459​.​ DOI: https://doi.org/10.1111/his.13375 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity​
    Chen, N.-M. ; Neeße, A. ; Dyck, M. L.; Steuber, B. ; König, A. O. ; Lubeseder-Martellato, C. & Winter, T. et al.​ (2017) 
    Gastroenterology, 152(6) pp. 1507​-+​.​ DOI: https://doi.org/10.1053/j.gastro.2017.01.043 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Partielles Ansprechen auf Crizotinib als Erstlinientherapie bei einem älteren männlichen Patienten mit ROS1-Translokations-positivem Bronchialkarzinom​
    Overbeck, T. R. ; Schmitz, K.; Engelke, C.; Sahlmann, C.-O. ; Hugo, S.; Kellner, L. & Trümper, L.  et al.​ (2016) 
    Karger-Kompass Onkologie, 3(2) pp. 97​-100​.​ DOI: https://doi.org/10.1159/000449192 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Diagnostic PD-L1 immunohistochemistry in NSCLC: Results of the first German harmonization study.​
    Scheel, A. H.; Dietel, M.; Heukamp, L. C.; Jöhrens, K.; Kirchner, T.; Reu, S. & Ruschoff, J.  et al.​ (2016) 
    Journal of Clinical Oncology, 34(15_suppl) pp. 3028​-3028​.​ DOI: https://doi.org/10.1200/JCO.2016.34.15_suppl.3028 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Occurrence of PDL1/2 copy number gains detected by FISH in adeno and squamous cell carcinomas of the lung and association with PDL1 overexpression in adenocarcinomas.​
    Schildhaus, H.-U. ; Richardt, P.; Wilsberg, L. & Schmitz, K.​ (2016) 
    Journal of Clinical Oncology, 34(15_suppl) pp. 3031​-3031​.​ DOI: https://doi.org/10.1200/JCO.2016.34.15_suppl.3031 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat​
    Angelika Ihle, M.; Merkelbach‐Bruse, S.; Hartmann, W.; Bauer, S. ; Ratner, N.; Sonobe, H. & Nishio, J. et al.​ (2016) 
    The Journal of Pathology, 2(2) pp. 59​-71​.​ DOI: https://doi.org/10.1002/cjp2.v2.2 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Partial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer​
    Overbeck, T. R. ; Schmitz, K.; Engelke, C.; Sahlmann, C.-O. ; Hugo, S.; Kellner, L. & Trümper, L.  et al.​ (2016) 
    Case Reports in Oncology, 9(1) pp. 158​-163​.​ DOI: https://doi.org/10.1159/000444745 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients​
    Michels, S.; Scheel, A. H. J.; Scheffler, M.; Schultheis, A. M.; Gautschi, O. P.; Aebersold, F. & Diebold, J. et al.​ (2016) 
    Journal of Thoracic Oncology, 11(1) pp. 122​-+​.​ DOI: https://doi.org/10.1016/j.jtho.2015.09.016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors​
    Ortiz-Cuaran, S.; Scheffler, M.; Plenker, D.; Dahmen, I.; Scheel, A. H.; Fernandez-Cuesta, L. & Meder, L. et al.​ (2016) 
    Clinical Cancer Research, 22(19) pp. 4837​-4847​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-15-1915 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Heterogeneity of colorectal cancer liver metastasis - analysis of WNT pathway patterns via High-throughput and bioinformatics profiling​
    Bleckmann, A. ; Wachter, A. ; Conradi, L.-C. ; Wolff, A. ; Hoppenau, C.; Korf, U. & Schildhaus, H.-U.  et al.​ (2015)
    Oncology Research and Treatment, 38 
    Basel​: Karger.
    ​Details  WoS 
  • 2015 | Journal Article
    ​ ​MET Amplification Status in Therapy-Naive Adeno- and Squamous Cell Carcinomas of the Lung​
    Schildhaus, H.-U. ; Schultheis, A. M.; Rüschoff, J. R. ; Binot, E.; Merkelbach-Bruse, S.; Fassunke, J. & Schulte, W. et al.​ (2015) 
    Clinical Cancer Research, 21(4) pp. 907​-915​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-14-0450 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​ROS1 rearrangement in non-small cell lung cancer (NSCLC): Prognostic and predicitve impact and genetic variability​
    Scheffler, M.; Schultheis, A.; Michels, S.; Teixido, C.; Hartmann, W.; Merkelbach-Bruse, S. & Sebastian, M. et al.​ (2014)
    Oncology Research and Treatment, 37 
    Basel​: Karger.
    ​Details  WoS 
  • 2010 | Journal Article | 
    ​ ​Pitfall in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors​
    Merkelbach-Bruse, S.; Dietmaier, W.; Fuezesi, L.; Gaumann, A.; Haller, F.; Kitz, J. & Krohn, A. et al.​ (2010) 
    BMC Medical Genetics, 11 art. 106​.​ DOI: https://doi.org/10.1186/1471-2350-11-106 
    ​Details  DOI  PMID  PMC  WoS 

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