RG Zelarayán-Behrend (Developmental Pharmacology)

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  • 2024 | Journal Article
    ​ ​Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​
    Knauer, C.; Haltern, H.; Schoger, E.; Kügler, S.; Roos, L.; Zelarayán, L. C. & Hasenfuss, G. et al.​ (2024) 
    Molecular Therapy - Nucleic Acids, 35(1) art. 102123​.​ DOI: https://doi.org/10.1016/j.omtn.2024.102123 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​
    Priesmeier, L.; Schoger, E.; Cyganek, L. & Zelarayán, L. C. ​ (2023) 
    Stem Cell Research, 71 pp. 103163​.​ DOI: https://doi.org/10.1016/j.scr.2023.103163 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling​
    Schoger, E.; Bleckwedel, F.; Germena, G.; Rocha, C.; Tucholla, P.; Sobitov, I. & Möbius, W.  et al.​ (2023) 
    Communications Biology, 6(1).​ DOI: https://doi.org/10.1038/s42003-022-04402-9 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview | 
    ​ ​Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine​
    Schoger, E.; Lelek, S.; Panáková, D. & Zelarayan, L. C. ​ (2022) 
    Frontiers in Cardiovascular Medicine, 8.​ DOI: https://doi.org/10.3389/fcvm.2021.783072 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe, 16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue​
    Bleckwedel, F.; Germena, G.; Hinkel, R.   & Zelarayán, L. C. ​ (2022) 
    Trillium Extracellular Vesicles, 4(1) pp. 26​-33​.​ DOI: https://doi.org/10.47184/tev.2022.01.03 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease​
    Shomroni, O. ; Sitte, M.; Schmidt, J.; Parbin, S.; Ludewig, F. ; Yigit, G.   & Zelarayan, L. C.  et al.​ (2022) 
    Scientific Reports, 12(1) art. 4091​.​ DOI: https://doi.org/10.1038/s41598-022-07874-1 
    ​Details  DOI  PMID  PMC 
  • 2021 | Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
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  • 2021 | Journal Article | Research Paper
    ​ ​Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival​
    Zelarayan, L. ; Vendrell, V.; Domínguez‐Frutos, E.; López‐Hernández, I.; Schimmang‐Alonso, K.; Alonso, M. T. & Alvarez, Y. et al.​ (2021) 
    Developmental Dynamics,.​ DOI: https://doi.org/10.1002/dvdy.435 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​A novel single-cell RNA-sequencing platform and its applicability connecting genotype to phenotype in ageing-disease​
    Shomroni, O.; Sitte, M.; Schmidt, J.; Parbin, S.; Ludewig, F.; Yigit, G.& Zelarayan, L. C.  et al.​ (2021). DOI: https://doi.org/10.21203/rs.3.rs-957427/v1 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​RhoGEF17—An Essential Regulator of Endothelial Cell Death and Growth​
    Weber, P.; Baltus, D.; Jatho, A.; Drews, O.; Zelarayan, L. C. ; Wieland, T. & Lutz, S. ​ (2021) 
    Cells, 10(4) pp. 741​.​ DOI: https://doi.org/10.3390/cells10040741 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 56 art. S1873506121003652​.​ DOI: https://doi.org/10.1016/j.scr.2021.102518 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice​
    Chen, Y.; Lüttmann, F. F.; Schoger, E.; Schöler, H. R.; Zelarayán, L. C. ; Kim, K.-P. & Haigh, J. J. et al.​ (2021) 
    Science, 373(6562) pp. 1537​-1540​.​ DOI: https://doi.org/10.1126/science.abg5159 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 55 art. S1873506121003202​.​ DOI: https://doi.org/10.1016/j.scr.2021.102473 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​
    Hofhuis, J. ; Bersch, K.; Wagner, S. ; Molina, C. E. ; Fakuade, F. E.; Iyer, L. M.   & Streckfuß-Bömeke, K.  et al.​ (2020) 
    Europace, 22(7) pp. 1119​-1131​.​ DOI: https://doi.org/10.1093/europace/euaa093 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart​
    Schoger, E.; Carroll, K. J.; Iyer, L. M. ; McAnally, J. R.; Tan, W.; Liu, N. & Noack, C.  et al.​ (2020) 
    Circulation Research, 126(1) pp. 6​-24​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.118.314522 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control​
    Rathjens, F. S. ; Blenkle, A.; Iyer, L. M. ; Renger, A.; Syeda, F.; Noack, C.   & Jungmann, A. et al.​ (2020) 
    Cardiovascular Research,.​ DOI: https://doi.org/10.1093/cvr/cvaa239 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​
    Schoger, E.; Argyriou, L.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2020) 
    Stem Cell Research, 48 pp. 101944​.​ DOI: https://doi.org/10.1016/j.scr.2020.101944 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium​
    Levent, E. ; Noack, C. ; Zelarayán, L. C. ; Katschinski, D. M. ; Zimmermann, W.-H.   & Tiburcy, M. ​ (2020) 
    Circulation, 142(17) pp. 1694​-1696​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044471 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium​
    Schlick, S. F. ; Spreckelsen, F.; Tiburcy, M. ; Iyer, L. M. ; Meyer, T. ; Zelarayan, L. C.   & Luther, S.  et al.​ (2019) 
    Progress in Biophysics and Molecular Biology, 144 pp. 51​-60​.​ DOI: https://doi.org/10.1016/j.pbiomolbio.2018.11.011 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​
    Noack, C. ; Iyer, L. M. ; Liaw, N. Y. ; Schoger, E.; Khadjeh, S. ; Wagner, E.   & Woelfer, M. et al.​ (2019) 
    Journal of the American College of Cardiology, 74(14) pp. 1804​-1819​.​ DOI: https://doi.org/10.1016/j.jacc.2019.07.076 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Overview | 
    ​ ​The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research​
    Gross, J. C. & Zelarayan, L. C. ​ (2018) 
    Frontiers in Cardiovascular Medicine, 5 art. 10​.​ DOI: https://doi.org/10.3389/fcvm.2018.00010 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper | 
    ​ ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​
    Iyer, L. M ; Nagarajan, S. ; Woelfer, M.; Schoger, E.; Khadjeh, S. ; Zafiriou, M. P.   & Kari, V.  et al.​ (2018) 
    Nucleic Acids Research, 46(6) pp. 2850​-2867​.​ DOI: https://doi.org/10.1093/nar/gky049 
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  • 2017 | Journal Article | Research Paper
    ​ ​B-catenin/TCF7L2 signaling orchestrates initiation of pathological hypertrophic cardiac remodeling by inducing chromatin modifications​
    Iyer, L. M. ; Noack, C.; Nagarajan, S.; Woelfer, M.; Schoger, E.; Pang, S. T. & Kari, V.  et al.​ (2017) 
    European Heart Journal, 38(suppl_1) art. P4479​.​ DOI: https://doi.org/10.1093/eurheartj/ehx504.P4479 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation​
    Noack, C. ; Haupt, L. P. ; Zimmermann, W.-H. ; Streckfuss-Bömeke, K.   & Zelarayán, L. C. ​ (2017) 
    Stem Cell Research, 23 pp. 127​-131​.​ DOI: https://doi.org/10.1016/j.scr.2017.07.007 
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  • 2017 | Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure, 10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts​
    Zafeiriou, M. P. ; Noack, C.   & Zelarayan, L. C. ​ (2016) 
    bio-protocol, 6(13) art. e1860​.​ DOI: https://doi.org/10.21769/BioProtoc.1860 
    ​Details  DOI 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction​
    Zafiriou, M. P. ; Noack, C. ; Unsoeld, B. W.; Didie, M. ; Pavlova, E.; Fischer, H. J.   & Reichardt, H. M.  et al.​ (2014) 
    STEM CELLS, 32(9) pp. 2480​-2491​.​ DOI: https://doi.org/10.1002/stem.1741 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription​
    Renger, A.; Zafiriou, M.-P. ; Noack, C. ; Pavlova, E.; Becker, A. ; Sharkova, K. & Bergmann, M. W. et al.​ (2013) 
    Stem Cells, 31(5) pp. 928​-940​.​ DOI: https://doi.org/10.1002/stem.1332 
    ​Details  DOI  PMID  PMC  WoS 

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