A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria

2006 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​A role for Tim21 in membrane-potential-dependent preprotein sorting in mitochondria​
van der Laan, M.; Wiedemann, N.; Mick, D. U. ; Guiard, B.; Rehling, P.   & Pfanner, N.​ (2006) 
Current Biology16(22) pp. 2271​-2276​.​ DOI: https://doi.org/10.1016/j.cub.2006.10.025 

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Authors
van der Laan, Martin; Wiedemann, Nils; Mick, David U. ; Guiard, Bernard; Rehling, Peter ; Pfanner, Nikolaus
Abstract
The mitochondrial inner membrane harbors complexes of the respiratory chain and translocase complexes for preproteins. The membrane potential generated by the respiratory chain is essential for ATP production by the mitochondrial ATP synthase and as a driving force for protein import [1-7]. It is generally believed that the preprotein translocases just use the membrane potential without getting into physical contact with respiratory-chain complexes [3, 6, 7]. Here, we show that the presequence translocase interacts with the respiratory chain. Tim21, a specific subunit of the sorting-active presequence translocase [8, 9], recruits proton-pumping respiratory-chain complexes and stimulates preprotein insertion. Thus, the presequence translocase cooperates with the respiratory chain and promotes membrane-potential-dependent protein sorting into the inner mitochondrial membrane. These findings suggest a new coupling mechanism in an energy-transducing membrane.
Issue Date
2006
Journal
Current Biology 
ISSN
0960-9822
Language
English

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