Mind the Organelle Gap - Peroxisome Contact Sites in Disease

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​Mind the Organelle Gap - Peroxisome Contact Sites in Disease​
Castro, I. G.; Schuldiner, M.   & Zalckvar, E.​ (2018) 
Trends in Biochemical Sciences43(3) pp. 199​-210​.​ DOI: https://doi.org/10.1016/j.tibs.2018.01.001 

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Authors
Castro, Inês Gomes; Schuldiner, Maya ; Zalckvar, Einat
Abstract
The eukaryotic cell is organized as a complex grid system where membrane-bound cellular compartments, organelles, must be localized to the right place at the right time. One way to facilitate correct organelle localization and organelle cooperation is through membrane contact sites, areas of close proximity between two organelles that are bridged by protein/lipid complexes. It is now clear that all organelles physically contact each other. The main focus of this review is contact sites of peroxisomes, central metabolic hubs whose defects lead to a variety of diseases. New peroxisome contacts, their tethering complexes and functions have been recently discovered. However, if and how peroxisome contacts contribute to the development of peroxisome-related diseases is still a mystery.
Issue Date
2018
Journal
Trends in Biochemical Sciences 
Project
SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente 
SFB 1190 | P11: Zuordnung zellulärer Kontaktstellen und deren Zusammenspiel 
Working Group
RG Schuldiner (Functional Genomics of Organelles) 
External URL
https://sfb1190.med.uni-goettingen.de/production/literature/publications/89
ISSN
0968-0004
Language
English

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