Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia

2022-10 | journal article; research paper

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​Autoantibodies against NMDAR subunit NR1 disappear from blood upon anesthesia​
Teller, J.; Jung, C.; Wilke, J. B. H.; Schimmelpfennig, S.-D.; Hindermann, M.; Hinken, L. & Gabriel, M. M. et al.​ (2022) 
Brain, behavior, & immunity - health24 art. 100494​.​ DOI: https://doi.org/10.1016/j.bbih.2022.100494 

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Authors
Teller, Johannes; Jung, Carolin; Wilke, Justus B. H.; Schimmelpfennig, Svea-Dorothée; Hindermann, Martin; Hinken, Lukas; Gabriel, Maria M.; Fegbeutel, Christine; Schäfer, Andreas; Laser, Hans; Lichtinghagen, Ralf; Worthmann, Hans; Weissenborn, Karin; Ehrenreich, Hannelore 
Abstract
Anesthetics penetrate the blood-brain-barrier (BBB) and - as confirmed preclinically - transiently disrupt it. An analogous consequence in humans has remained unproven. In mice, we previously reported that upon BBB dysfunction, the brain acts as 'immunoprecipitator' of autoantibodies against N-methyl-D-aspartate-receptor subunit-NR1 (NMDAR1-AB). We thus hypothesized that during human anesthesia, pre-existing NMDAR1-AB will specifically bind to brain. Screening of N = 270 subjects undergoing general anesthesia during cardiac surgery for serum NMDAR1-AB revealed N = 25 NMDAR1-AB seropositives. Only N = 14 remained positive post-surgery. No changes in albumin, thyroglobulin or CRP were associated with reduction of serum NMDAR1-AB. Thus, upon anesthesia, BBB opening likely occurs also in humans.
Issue Date
October-2022
Journal
Brain, behavior, & immunity - health 
Project
TRR 274: Checkpoints of Central Nervous System Recovery 
TRR 274 | C01: Oligodendroglial NMDA receptors and NMDAR1 autoantibodies as determinants of axonal integrity in neuropsychiatric disease 
Working Group
RG Ehrenreich (Clinical Neuroscience) 
External URL
https://rdp.sfb274.de/literature/publications/74
eISSN
2666-3546
Language
English

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