NLR we there yet? Nucleocytoplasmic coordination of NLR-mediated immunity

2022 | journal article. A publication with affiliation to the University of Göttingen.

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​NLR we there yet? Nucleocytoplasmic coordination of NLR-mediated immunity​
Lüdke, D.; Yan, Q.; Rohmann, P. F. W. & Wiermer, M. ​ (2022) 
New Phytologist, art. nph.18359​.​ DOI: https://doi.org/10.1111/nph.18359 

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Authors
Lüdke, Daniel; Yan, Qiqi; Rohmann, Philipp F. W.; Wiermer, Marcel 
Abstract
Plant intracellular nucleotide-binding leucine-rich repeat immune receptors (NLRs) perceive theactivity of pathogen-secreted effector molecules that, when undetected, promote colonisation ofhosts.SignallingfromactivatedNLRsconvergeswithandpotentiatesdownstreamresponsesfromactivated pattern recognition receptors (PRRs) that sense microbial signatures at the cell surface.Efficient signalling of both receptor branches relies on the host cell nucleus as an integration pointfor transcriptional reprogramming, and on the macromolecular transport processes that mediatethe communication between cytoplasm and nucleoplasm. Studies on nuclear pore complexes(NPCs), the nucleoporin proteins (NUPs) that compose NPCs, and nuclear transport machineryconstituentsthatcontrolnucleocytoplasmictransport,haverevealedthattheyplayimportantrolesin regulating plant immune responses. Here, we discuss the contributions of nucleoporins andnucleartransportreceptor(NTR)-mediatedsignaltransductioninplantimmunitywithanemphasison NLR immune signalling across the nuclear compartment boundary and within the nucleus. Wealso highlight and discuss cytoplasmic and nuclear functions of NLRs and their signalling partnersandfurtherconsiderthepotentialimplicationsofNLRactivationandresistosomeformationinbothcellular compartments for mediating plant pathogen resistance and programmed host cell deat.
Issue Date
2022
Journal
New Phytologist 
Organization
Albrecht-von-Haller-Institut für Pflanzenwissenschaften ; Abteilung Molekularbiologie und Physiologie der Pflanze 
ISSN
0028-646X
eISSN
1469-8137
Language
English
Sponsor
Deutsche Forschungsgemeinschaft https://doi.org/10.13039/501100001659
Gatsby Charitable Foundation https://doi.org/10.13039/501100000324

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