Sustained Increase in Serum Glial Fibrillary Acidic Protein after First ST-Elevation Myocardial Infarction

2022 | journal article. A publication with affiliation to the University of Göttingen.

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​Traub, J., Grondey, K., Gassenmaier, T., Schmitt, D., Fette, G., Frantz, S., Boivin-Jahns, V. ... Frey, A. (2022). ​Sustained Increase in Serum Glial Fibrillary Acidic Protein after First ST-Elevation Myocardial Infarction. International Journal of Molecular Sciences23(18), Article 10304​. ​doi: https://doi.org/10.3390/ijms231810304 

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Authors
Traub, Jan; Grondey, Katja; Gassenmaier, Tobias; Schmitt, Dominik; Fette, Georg; Frantz, Stefan; Boivin-Jahns, Valérie; Jahns, Roland; Störk, Stefan; Stoll, Guido; Frey, Anna
Abstract
Acute ischemic cardiac injury predisposes one to cognitive impairment, dementia, and depression. Pathophysiologically, recent positron emission tomography data suggest astroglial activation after experimental myocardial infarction (MI). We analyzed peripheral surrogate markers of glial (and neuronal) damage serially within 12 months after the first ST-elevation MI (STEMI). Serum levels of glial fibrillary acidic protein (GFAP) and neurofilament light chain (NfL) were quantified using ultra-sensitive molecular immunoassays. Sufficient biomaterial was available from 45 STEMI patients (aged 28 to 78 years, median 56 years, 11% female). The median (quartiles) of GFAP was 63.8 (47.0, 89.9) pg/mL and of NfL 10.6 (7.2, 14.8) pg/mL at study entry 0–4 days after STEMI. GFAP after STEMI increased in the first 3 months, with a median change of +7.8 (0.4, 19.4) pg/mL (p = 0.007). It remained elevated without further relevant increases after 6 months (+11.7 (0.6, 23.5) pg/mL; p = 0.015), and 12 months (+10.3 (1.5, 22.7) pg/mL; p = 0.010) compared to the baseline. Larger relative infarction size was associated with a higher increase in GFAP (ρ = 0.41; p = 0.009). In contrast, NfL remained unaltered in the course of one year. Our findings support the idea of central nervous system involvement after MI, with GFAP as a potential peripheral biomarker of chronic glial damage as one pathophysiologic pathway.
Issue Date
2022
Journal
International Journal of Molecular Sciences 
Organization
Institut für Neuropathologie ; Klinik für Neurologie ; Universitätsmedizin Göttingen 
eISSN
1422-0067
Language
English

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