Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19

2022 | journal article; research paper. A publication of Göttingen

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​Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19​
Homann, S.; Mikuteit, M.; Niewolik, J.; Behrens, G.; Stölting, A.; Müllenmeister, C. & El-Sayed, I. et al.​ (2022) 
International Journal of Environmental Research and Public Health19(16) art. 9924​.​ DOI: https://doi.org/10.3390/ijerph19169924 

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Homann, Stefanie; Mikuteit, Marie; Niewolik, Jacqueline; Behrens, Georg; Stölting, Andrea; Müllenmeister, Christina; El-Sayed, Iman; Happle, Christine; Steffens, Sandra; Jablonka, Alexandra; Müller, Frank ; Schröder, Dominik ; Heinemann, Stephanie 
<jats:p>Background: Patients who are post-COVID-19 will require more treatment soon. Therefore, it is important to understand the root cause of their psychological and somatic conditions. Previous studies showed contradictory results on the influence of pre-existing mental conditions. The present study examines the influence of these pre-existing conditions and their pre-treatment on the severity of post-COVID-19 symptoms. Methods: This analysis employs questionnaire data from a large study sample in Germany. Overall, 801 participants were included. All participants rated their health status on a scale from 0 to 100. Fatigue, depression, and anxiety were measured using the FAS, PHQ-9, and GAD-7 scales. Results: All pre-pandemic values showed no significant differences between the groups. The current health status was rated similarly by the recovered patients (μ = 80.5 ± 17.0) and the control group (μ = 81.2 ± 18.0) but significantly worse by acutely infected (μ = 59.0 ± 21.5) and post-COVID-19 patients (μ = 54.2 ± 21.1). Fatigue, depression, and anxiety were similar for recovered patients and the control group. By contrast, there were significant differences between the control and the post-COVID-19 groups concerning fatigue (45.9% vs. 93.1%), depression (19.3% vs. 53.8%), and anxiety (19.3% vs. 22.3%). Conclusion: Fatigue and psychological conditions of post-COVID-19 patients are not associated with pre-existing conditions.</jats:p>
Issue Date
International Journal of Environmental Research and Public Health 
DEFEnse Against COVID-19 STudy 
Institut für Allgemeinmedizin 



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