Plasticity of Mitochondrial Translation

2017 | journal article

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​Plasticity of Mitochondrial Translation​
Dennerlein, S. ; Wang, C.   & Rehling, P. ​ (2017) 
Trends in Cell Biology27(10) pp. 712​-721​.​ DOI: https://doi.org/10.1016/j.tcb.2017.05.004 

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Authors
Dennerlein, Sven ; Wang, Cong ; Rehling, Peter 
Abstract
Mitochondria maintained a genome during evolution to synthesize core subunits of the oxidative phosphorylation system. Expression of the mitochondrial genome requires intraorganellar replication, transcription, and translation. Membrane-associated ribosomes translate mitochondrial-encoded proteins and facilitate co-translational insertion of newly synthesized polypeptides into the inner membrane. Considering that mitochondrial-encoded proteins assemble with imported, nuclear-encoded proteins into enzyme complexes of the oxidative phosphorylation system, it is expected that expression of mitochondrial genes should adapt to the availability of their nuclear-encoded partners. Recent work shows that mitochondrial translation is influenced by the cellular environment. We discuss how mitochondrial translation is affected by the cellular environment and propose models of translational plasticity that modulate mitochondrial translation in response to the availability of imported proteins.
Issue Date
2017
Journal
Trends in Cell Biology 
eISSN
1879-3088
Language
English

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