Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system

2017-03-04 | journal article. A publication with affiliation to the University of Göttingen.

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​Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system​
Richter, S.; Helm, C.; Meunier, F. A.; Hering, L.; Campbell, L. I.; Drukewitz, S. H. & Undheim, E. A. B. et al.​ (2017) 
BMC Evolutionary Biology17(1) art. 64​.​ DOI: https://doi.org/10.1186/s12862-017-0904-4 

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Authors
Richter, Sandy; Helm, Conrad; Meunier, Frederic A.; Hering, Lars; Campbell, Lahcen I.; Drukewitz, Stephan H.; Undheim, Eivind A. B.; Jenner, Ronald A.; Schiavo, Giampietro; Bleidorn, Christoph 
Abstract
We present the first molecular characterization of glycerotoxin (GLTx), a potent neurotoxin found in the venom of the bloodworm Glycera tridactyla (Glyceridae, Annelida). Within the animal kingdom, GLTx shows a unique mode of action as it can specifically up-regulate the activity of Cav2.2 channels (N-type) in a reversible manner. The lack of sequence information has so far hampered a detailed understanding of its mode of action.
Issue Date
4-March-2017
Journal
BMC Evolutionary Biology 
eISSN
1471-2148
Language
English

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