Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system

2017-03-04 | journal article. A publication with affiliation to the University of Göttingen.

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​Richter, S., Helm, C., Meunier, F. A., Hering, L., Campbell, L. I., Drukewitz, S. H., Undheim, E. A. B. ... Bleidorn, C. (2017). ​Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system. BMC Evolutionary Biology17(1), Article 64​. ​doi: https://doi.org/10.1186/s12862-017-0904-4 

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Authors
Richter, Sandy; Helm, Conrad; Meunier, Frederic A.; Hering, Lars; Campbell, Lahcen I.; Drukewitz, Stephan H.; Undheim, Eivind A. B.; Jenner, Ronald A.; Schiavo, Giampietro; Bleidorn, Christoph 
Abstract
We present the first molecular characterization of glycerotoxin (GLTx), a potent neurotoxin found in the venom of the bloodworm Glycera tridactyla (Glyceridae, Annelida). Within the animal kingdom, GLTx shows a unique mode of action as it can specifically up-regulate the activity of Cav2.2 channels (N-type) in a reversible manner. The lack of sequence information has so far hampered a detailed understanding of its mode of action.
Issue Date
4-March-2017
Journal
BMC Evolutionary Biology 
eISSN
1471-2148
Language
English

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