Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system

2017-03-04 | journal article. A publication with affiliation to the University of Göttingen.

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​Richter, Sandy, Conrad Helm, Frederic A. Meunier, Lars Hering, Lahcen I. Campbell, Stephan H. Drukewitz, Eivind A. B. Undheim, Ronald A. Jenner, Giampietro Schiavo, and Christoph Bleidorn. "Comparative analyses of glycerotoxin expression unveil a novel structural organization of the bloodworm venom system​." ​BMC Evolutionary Biology ​17, no. 1 (2017): ​64​. ​https://doi.org/10.1186/s12862-017-0904-4.

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Authors
Richter, Sandy; Helm, Conrad; Meunier, Frederic A.; Hering, Lars; Campbell, Lahcen I.; Drukewitz, Stephan H.; Undheim, Eivind A. B.; Jenner, Ronald A.; Schiavo, Giampietro; Bleidorn, Christoph 
Abstract
We present the first molecular characterization of glycerotoxin (GLTx), a potent neurotoxin found in the venom of the bloodworm Glycera tridactyla (Glyceridae, Annelida). Within the animal kingdom, GLTx shows a unique mode of action as it can specifically up-regulate the activity of Cav2.2 channels (N-type) in a reversible manner. The lack of sequence information has so far hampered a detailed understanding of its mode of action.
Issue Date
4-March-2017
Journal
BMC Evolutionary Biology 
eISSN
1471-2148
Language
English

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