Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein

2016 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​Mitochondrial Protein Synthesis Adapts to Influx of Nuclear-Encoded Protein​
Richter-Dennerlein, R. ; Oeljeklaus, S.; Lorenzi, I.; Ronsör, C.; Bareth, B. ; Schendzielorz, A. B.   & Wang, C.  et al.​ (2016) 
Cell167(2) pp. 471​-310​.​ DOI: https://doi.org/10.1016/j.cell.2016.09.003 

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Authors
Richter-Dennerlein, Ricarda ; Oeljeklaus, Silke; Lorenzi, Isotta; Ronsör, Christin; Bareth, Bettina ; Schendzielorz, Alexander Benjamin ; Wang, Cong ; Warscheid, Bettina; Rehling, Peter ; Dennerlein, Sven 
Abstract
Mitochondrial ribosomes translate membrane integral core subunits of the oxidative phosphorylation system encoded by mtDNA. These translation products associate with nuclear-encoded, imported proteins to form enzyme complexes that produce ATP. Here, we show that human mitochondrial ribosomes display translational plasticity to cope with the supply of imported nuclear-encoded subunits. Ribosomes expressing mitochondrial-encoded COX1 mRNA selectively engage with cytochrome c oxidase assembly factors in the inner membrane. Assembly defects of the cytochrome c oxidase arrest mitochondrial translation in a ribosome nascent chain complex with a partially membrane-inserted COX1 translation product. This complex represents a primed state of the translation product that can be retrieved for assembly. These findings establish a mammalian translational plasticity pathway in mitochondria that enables adaptation of mitochondrial protein synthesis to the influx of nuclear-encoded subunits.
Issue Date
2016
Journal
Cell 
ISSN
0092-8674
eISSN
1097-4172
Language
English

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