3d Virtual Histology Reveals Pathological Alterations of Cerebellar Granule Cells in Multiple Sclerosis
2023-04-13 | journal article. A publication of Göttingen
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3d Virtual Histology Reveals Pathological Alterations of Cerebellar Granule Cells in Multiple Sclerosis
Frost, J.; Schmitzer, B. ; Töpperwien, M.; Eckermann, M.; Franz, J.; Stadelmann, C. & Salditt, T. (2023)
Neuroscience,. DOI: https://doi.org/10.1016/j.neuroscience.2023.04.002
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Details
- Authors
- Frost, Jakob; Schmitzer, Bernhard ; Töpperwien, Mareike; Eckermann, Marina; Franz, Jonas; Stadelmann, Christine ; Salditt, Tim
- Abstract
- We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze data recorded by X-ray phase contrast tomography from tissue samples collected post mortem from a MS and a healthy control group. Using automated segmentation and histogram analysis based on optimal transport theory (OT) we find that the distributions representing nuclear structure in the granular layer move to a more compact nuclear state, i.e. smaller, denser and more heterogeneous nuclei in MS. We have previously made a similar observation for neurons of the dentate gyrus in Alzheimer's disease, suggesting that more compact structure of neuronal nuclei which we attributed to increased levels of heterochromatin, may possibly represent a more general phenomenon of cellular senescence associated with neurodegeneration.
- Issue Date
- 13-April-2023
- Journal
- Neuroscience
- Project
- EXC 2067: Multiscale Bioimaging
SFB 1456: Mathematik des Experiments: Die Herausforderung indirekter Messungen in den Naturwissenschaften
SFB 1456 | Cluster A | A03: Dimensionality reduction and regression in Wasserstein space for quantitative 3D histology - Organization
- Institut für Röntgenphysik ; Institut für Informatik ; Institut für Neuropathologie
- Working Group
- RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics)
RG Stadelmann-Nessler - ISSN
- 0306-4522
- eISSN
- 1873-7544
- Language
- English