3d Virtual Histology Reveals Pathological Alterations of Cerebellar Granule Cells in Multiple Sclerosis

2023-04-13 | journal article. A publication with affiliation to the University of Göttingen.

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​Frost J, Schmitzer B, Töpperwien M, Eckermann M, Franz J, Stadelmann C, et al. ​3d Virtual Histology Reveals Pathological Alterations of Cerebellar Granule Cells in Multiple Sclerosis​. ​​Neuroscience. ​2023;. ​doi:10.1016/j.neuroscience.2023.04.002. 

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Authors
Frost, Jakob; Schmitzer, Bernhard ; Töpperwien, Mareike; Eckermann, Marina; Franz, Jonas; Stadelmann, Christine ; Salditt, Tim 
Abstract
We investigate structural properties of neurons in the granular layer of human cerebellum with respect to their involvement in multiple sclerosis (MS). To this end we analyze data recorded by X-ray phase contrast tomography from tissue samples collected post mortem from a MS and a healthy control group. Using automated segmentation and histogram analysis based on optimal transport theory (OT) we find that the distributions representing nuclear structure in the granular layer move to a more compact nuclear state, i.e. smaller, denser and more heterogeneous nuclei in MS. We have previously made a similar observation for neurons of the dentate gyrus in Alzheimer's disease, suggesting that more compact structure of neuronal nuclei which we attributed to increased levels of heterochromatin, may possibly represent a more general phenomenon of cellular senescence associated with neurodegeneration.
Issue Date
13-April-2023
Journal
Neuroscience 
Project
EXC 2067: Multiscale Bioimaging 
SFB 1456: Mathematik des Experiments: Die Herausforderung indirekter Messungen in den Naturwissenschaften 
SFB 1456 | Cluster A | A03: Dimensionality reduction and regression in Wasserstein space for quantitative 3D histology 
Organization
Institut für Röntgenphysik ; Institut für Informatik ; Institut für Neuropathologie 
Working Group
RG Salditt (Structure of Biomolecular Assemblies and X-Ray Physics) 
RG Stadelmann-Nessler 
ISSN
0306-4522
eISSN
1873-7544
Language
English

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