Age-dependent structural reorganization of utricular ribbon synapses

2023 | journal article. A publication with affiliation to the University of Göttingen.

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​Age-dependent structural reorganization of utricular ribbon synapses​
Michanski, S.; Henneck, T.; Mukhopadhyay, M.; Steyer, A. M.; Gonzalez, P. A.; Grewe, K. & Ilgen, P. et al.​ (2023) 
Frontiers in Cell and Developmental Biology11 art. 1178992​.​ DOI: 

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Michanski, Susann; Henneck, Timo; Mukhopadhyay, Mohona; Steyer, Anna M.; Gonzalez, Paola Agüi; Grewe, Katharina; Ilgen, Peter; Gültas, Mehmet; Fornasiero, Eugenio F.; Jakobs, Stefan; Wichmann, Carolin
In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the vestibular labyrinth. Vestibular hair cells (VHCs) harbor synaptic ribbons at their presynaptic active zones (AZs), which play a critical role in molecular scaffolding and facilitate synaptic release and vesicular replenishment. With advancing age, the prevalence of vestibular deficits increases; yet, the underlying mechanisms are not well understood and the possible accompanying morphological changes in the VHC synapses have not yet been systematically examined. We investigated the effects of maturation and aging on the ultrastructure of the ribbon-type AZs in murine utricles using various electron microscopic techniques and combined them with confocal and super-resolution light microscopy as well as metabolic imaging up to 1 year of age. In older animals, we detected predominantly in type I VHCs the formation of floating ribbon clusters, mostly consisting of newly synthesized ribbon material. Our findings suggest that VHC ribbon-type AZs undergo dramatic structural alterations upon aging.
Issue Date
Frontiers in Cell and Developmental Biology 
EXC 2067: Multiscale Bioimaging 
SFB 1286: Quantitative Synaptologie 
SFB 1286 | A03: Dynamische Analyse der Remodellierung der extrazellulären Matrix (ECM) als Mechanismus der Synapsenorganisation und Plastizität 
SFB 1286 | A04: Aktivitätsabhängige morphologische Veränderungen am Endkolben von Held-Synapsen 
SFB 1286 | A05: Mitochondriale Heterogenität in Synapsen 
FOR 2848: Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala 
FOR 2848 | P08: Strukturelle und funktionale Veränderungen der inneren mitochondrialen Membran axonaler Mitochondrien in vivo in einem dymyelinisierenden Mausmodell 
Working Group
RG Jakobs (Structure and Dynamics of Mitochondria) 
RG Möbius 
RG Pangršič Vilfan (Experimental Otology) 
RG Rizzoli (Quantitative Synaptology in Space and Time) 
RG Wichmann (Molecular Architecture of Synapses) 
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