Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

2021 | journal article. A publication with affiliation to the University of Göttingen.

Erratum to this publication

Jump to:Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Demontis, Ditte, Raymond K. Walters, Veera M. Rajagopal, Irwin D. Waldman, Jakob Grove, Thomas D. Als, Søren Dalsgaard et al. "Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder​." ​Nature Communications ​12, no. 1 (2021): . ​https://doi.org/10.1038/s41467-020-20443-2.

Documents & Media

License

GRO License GRO License

Details

Authors Group
ADHD Working Group of the Psychiatric Genomics Consortium (PGC)
The authors list is uncomplete:
Authors
Demontis, Ditte; Walters, Raymond K.; Rajagopal, Veera M.; Waldman, Irwin D.; Grove, Jakob; Als, Thomas D.; Dalsgaard, Søren; Ribasés, Marta; Bybjerg-Grauholm, Jonas; Bækvad-Hansen, Maria; Børglum, Anders D.
Abstract
Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on chromosome 11 is a strong risk locus for ADHD + DBDs across European and Chinese ancestries (rs7118422, P = 3.15×10 −10 , OR = 1.17). We find a higher SNP heritability for ADHD + DBDs (h 2 SNP  = 0.34) when compared to ADHD without DBDs (h 2 SNP  = 0.20), high genetic correlations between ADHD + DBDs and aggressive (r g  = 0.81) and anti-social behaviors (r g  = 0.82), and an increased burden (polygenic score) of variants associated with ADHD and aggression in ADHD + DBDs compared to ADHD without DBDs. Our results suggest an increased load of common risk variants in ADHD + DBDs compared to ADHD without DBDs, which in part can be explained by variants associated with aggressive behavior.
Issue Date
2021
Journal
Nature Communications 
eISSN
2041-1723
Language
English

Reference

Citations


Social Media