Cite this publication
Quantitative assessment of left ventricular mechanical dyssynchrony using cine cardiovascular magnetic resonance imaging: Inter-study reproducibility
Kowallick, J. T. ; Morton, G.; Lamata, P.; Jogiya, R.; Kutty, S.; Hasenfuß, G. & Lotz, J. et al. (2017)
JRSM Cardiovascular Disease, 6 art. 204800401771014.
- Kowallick, Johannes T. ; Morton, Geraint; Lamata, Pablo; Jogiya, Roy; Kutty, Shelby; Hasenfuß, Gerd ; Lotz, Joachim ; Chiribiri, Amedeo; Nagel, Eike; Schuster, Andreas
- Objectives: To determine the inter-study reproducibility of left ventricular (LV) mechanical dyssynchrony measures based on standard cardiovascular magnetic resonance (CMR) cine images. Design: Steady-state free precession (SSFP) LV short-axis stacks and three long-axes were acquired on the same day at three time points. Circumferential strain systolic dyssynchrony indexes (SDI), area-SDI as well as circumferential and radial uniformity ratio estimates (CURE and RURE, respectively) were derived from CMR myocardial feature-tracking (CMR-FT) based on the tracking of three SSFP short-axis planes. Furthermore, 4D-LV-analysis based on SSFP short-axis stacks and longitudinal planes was performed to quantify 4D-volume-SDI. Setting: A single-centre London teaching hospital. Participants: 16 healthy volunteers. Main outcome measures: Inter-study reproducibility between the repeated exams. Results: CURE and RURE as well as 4D-volume-SDI showed good inter-study reproducibility (coefficient of variation [CoV] 6.4%–12.9%). Circumferential strain and area-SDI showed higher variability between the repeated measurements (CoV 24.9%–37.5%). Uniformity ratio estimates showed the lowest inter-study variability (CoV 6.4%–8.5%). Conclusions: Derivation of LV mechanical dyssynchrony measures from standard cine images is feasible using CMR-FT and 4D-LV-analysis tools. Uniformity ratio estimates and 4D-volume-SDI showed good inter-study reproducibility. Their clinical value should next be explored in patients who potentially benefit from cardiac resynchronization therapy.
- Issue Date
- JRSM Cardiovascular Disease
- Open-Access-Publikationsfonds 2017