Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses

2023 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​Diversity matters — extending sound intensity coding by inner hair cells via heterogeneous synapses​
Moser, T.; Karagulyan, N.; Neef, J.   & Jaime Tobón, L. M.​ (2023) 
The EMBO Journal, art. e114587​.​ DOI: https://doi.org/10.15252/embj.2023114587 

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Authors
Moser, Tobias; Karagulyan, Nare; Neef, Jakob ; Jaime Tobón, Lina María
Abstract
Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal precision is an enigmatic phenomenon of the auditory system. Downstream of dynamic range compression by active cochlear micromechanics, the inner hair cells (IHCs) cover the full intensity range of sound input. Yet, the firing rate in each of their postsynaptic spiral ganglion neurons (SGNs) encodes only a fraction of it. As a population, spiral ganglion neurons with their respective individual coding fractions cover the entire audible range. How such “dynamic range fractionation” arises is a topic of current research and the focus of this review. Here, we discuss mechanisms for generating the diverse functional properties of SGNs and formulate testable hypotheses. We postulate that an interplay of synaptic heterogeneity, molecularly distinct subtypes of SGNs, and efferent modulation serves the neural decomposition of sound information and thus contributes to a population code for sound intensity.
Issue Date
2023
Journal
The EMBO Journal 
Project
EXC 2067: Multiscale Bioimaging 
SFB 889: Zelluläre Mechanismen sensorischer Verarbeitung 
info:eu-repo/grantAgreement/null/null/101054467/null/Solving the dynamic range problem of hearing: deciphering and harnessing cochlear mechanisms of sound intensity coding
Working Group
RG Moser (Molecular Anatomy, Physiology and Pathology of Sound Encoding) 
External URL
https://mbexc.uni-goettingen.de/literature/publications/765
ISSN
0261-4189
eISSN
1460-2075
Language
English
Fulltext
https://www.embopress.org/doi/epdf/10.15252/embj.2023114587
Notes
Project: Fondation pour l'Audition (FPARD-2020-10)

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