Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins

2011 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​Exocytosis at the hair cell ribbon synapse apparently operates without neuronal SNARE proteins​
Nouvian, R. ; Neef, J. ; Bulankina, A. V; Reisinger, E. ; Pangršič, T. ; Frank, T.   & Sikorra, S. et al.​ (2011) 
Nature Neuroscience14(4) pp. 411​-413​.​ DOI: https://doi.org/10.1038/nn.2774 

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Authors
Nouvian, Régis ; Neef, Jakob ; Bulankina, Anna V; Reisinger, Ellen ; Pangršič, Tina ; Frank, Thomas ; Sikorra, Stefan; Brose, Nils ; Binz, Thomas; Moser, Tobias 
Abstract
SNARE proteins mediate membrane fusion. Neurosecretion depends on neuronal soluble NSF attachment protein receptors ( SNAREs; SNAP-25, syntaxin-1, and synaptobrevin-1 or synaptobrevin-2) and is blocked by neurotoxin-mediated cleavage or genetic ablation. We found that exocytosis in mouse inner hair cells (IHCs) was insensitive to neurotoxins and genetic ablation of neuronal SNAREs. mRNA, but no synaptically localized protein, of neuronal SNAREs was present in IHCs. Thus, IHC exocytosis is unconventional and may operate independently of neuronal SNAREs.
Issue Date
2011
Journal
Nature Neuroscience 
ISSN
1097-6256
Language
English

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