Serum Levels of Interleukin-6 and Interleukin-10 in Relation to Depression Scores in Patients with Cardiovascular Risk Factors

2011 | journal article; research paper. A publication of Göttingen

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​Serum Levels of Interleukin-6 and Interleukin-10 in Relation to Depression Scores in Patients with Cardiovascular Risk Factors​
Meyer, T.; Stanske, B.; Kochen, M. M. ; Cordes, A.; Yueksel, I.; Wachter, R. R. & Lueers, C. et al.​ (2011) 
Behavioral Medicine37(3) pp. 105​-112​.​ DOI: 

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Meyer, Thomas; Stanske, Beate; Kochen, Michael M. ; Cordes, Andreas; Yueksel, Iraz; Wachter, R. Rolf; Lueers, Claus; Scherer, Martin; Binder, Lutz; Pieske, Burkert M.; Herrmann-Lingen, Christoph
It is currently unknown whether elevated cytokine levels in depression are confined to any specific subgroup of depressive patients. In this study, medical out-patients presenting with cardiovascular risk factors (N = 356) were assessed for both cognitive-affective and physical symptoms of depression using the Hospital Anxiety and Depression Scale (HADS) and the Maastricht questionnaire (MQ), respectively. In study participants assigned to the highest (>= 21) and lowest (<= 5) quartile for the MQ score, serum levels of cytokines were measured. We found highly significant associations between cognitive-affective symptoms of depression and elevated serum levels of interleukin-6 (IL-6; rho = .231; p = .002) and interleukin-10 (IL-10; rho = .370; p < .001), respectively. In multiple regression models elevated IL-10 serum concentration was independently related to cognitive-affective symptoms of depression (rho = .165; p = .002). When all cytokines were included in one model, elevated IL-10 serum concentrations remained a significant predictor for depressive mood (rho = .157; p = .009). In patients with cardiovascular risk factors and extreme scores for vital exhaustion, elevated serum IL-6 and even more IL-10 concentrations are linked to the presence of depressive mood. Future studies will have to test whether the so far unreported association of IL-10 with depressive mood represents a causal pathway involved in the pathogenesis or in the prognostic effect of depressive mood in cardiac patients.
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Behavioral Medicine 
Institut für Allgemeinmedizin 



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