Inhaled beta-agonist does not modify sympathetic activity in patients with COPD

2015 | journal article; research paper. A publication with affiliation to the University of Göttingen.

Jump to: Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Inhaled beta-agonist does not modify sympathetic activity in patients with COPD​
Haarmann, H. ; Mohrlang, C.; Tschiesner, U.; Rubin, D. B.; Bornemann, T.; Rueter, K. & Bonev, S. et al.​ (2015) 
BMC Pulmonary Medicine15 art. 46​.​ DOI: 

Documents & Media

12890_2015_Article_54.pdf772.51 kBAdobe PDF


Published Version

Attribution 4.0 CC BY 4.0


Haarmann, Helge ; Mohrlang, Cordula; Tschiesner, Uta; Rubin, David B.; Bornemann, Thore; Rueter, Karin; Bonev, Slavtcho; Raupach, Tobias ; Hasenfuß, Gerd ; Andreas, Stefan 
Background: Neurohumoral activation is present in COPD and might provide a link between pulmonary and systemic effects, especially cardiovascular disease. Because long acting inhaled beta-agonists reduce hyperinflation, they could reduce sympathoexcitation by improving the inflation reflex. We aimed to evaluate if inhaled therapy with salmeterol reduces muscle sympathetic nerve activity (MSNA) evaluated by microneurography. Methods: MSNA, heart rate, blood pressure, and respiration were continually measured. After baseline recording of 20 minutes, placebo was administered; after further 45 minutes salmeterol (50 mu g) was administered which was followed by a further 45 minutes of data recording. Additionally, lung function, plasma catecholamine levels, arterial pulse wave velocity, heart rate variability, and baroreflex sensitivity were evaluated. Following 4 weeks of treatment with salmeterol 50 mu g twice daily, measurements were repeated without placebo administration. Results: A total of 32 COPD patients were included. Valid MSNA signals were obtained from 18 patients. Change in MSNA (bursts/100 heart beats) following acute administration of salmeterol did not differ significantly from the change following placebo (-1.96 +/- 9.81 vs. -0.65 +/- 9.07; p = 0.51) although hyperinflation was significantly reduced. Likewise, no changes in MSNA or catecholamines were observed after 4 weeks. Heart rate increased significantly by 3.8 +/- 4.2 (p < 0.01) acutely and 3.9 +/- 4.3 bpm (p < 0.01) after 4 weeks. Salmeterol treatment was safe and well tolerated. Conclusions: By using microneurography as a gold standard to evaluate sympathetic activity we found no change in MSNA following salmeterol inhalation. Thus, despite an attenuation of hyperinflation, the long acting beta-agonist salmeterol does not appear to reduce nor incite sympathoexcitation.
Issue Date
Biomed Central Ltd
BMC Pulmonary Medicine 



Social Media