Cross-linked biopolymer bundles: Cross-link reversibility leads to cooperative binding/unbinding phenomena

2012 | journal article. A publication of Göttingen

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​Cross-linked biopolymer bundles: Cross-link reversibility leads to cooperative binding/unbinding phenomena​
Vink, R. L. C. & Heussinger, C.​ (2012) 
The Journal of Chemical Physics136(3) art. 035102​.​ DOI: 

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Vink, Richard L. C.; Heussinger, Claus
We consider a biopolymer bundle consisting of filaments that are cross-linked together. The cross-links are reversible: they can dynamically bind and unbind adjacent filament pairs as controlled by a binding enthalpy. The bundle is subjected to a bending deformation and the corresponding distribution of cross-links is measured. For a bundle consisting of two filaments, upon increasing the bending amplitude, a first-order transition is observed. The transition is from a state where the filaments are tightly coupled by many bound cross-links, to a state of nearly independent filaments with only a few bound cross-links. For a bundle consisting of more than two filaments, a series of first-order transitions is observed. The transitions are connected with the formation of an interface between regions of low and high cross-link densities. Combining umbrella sampling Monte Carlo simulations with analytical calculations, we present a detailed picture of how the competition between cross-link shearing and filament stretching drives the transitions. We also find that, when the cross-links become soft, collective behavior is not observed: the cross-links then unbind one after the other leading to a smooth decrease of the average cross-link density. (C) 2012 American Institute of Physics. [doi:10.1063/1.3675832]
Issue Date
Amer Inst Physics
The Journal of Chemical Physics 
1089-7690; 0021-9606
Deutsche Forschungsgemeinschaft (DFG) [VI 483/1-1]



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