Cite this publication
Adaptive Aggregation of Peptide Model Systems
Lee, J. J.; Albrecht, M.; Rice, C. A. & Suhm, M. A. (2013)
The Journal of Physical Chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory, 117(32) pp. 7050-7063. DOI: https://doi.org/10.1021/jp400056n
Documents & Media
- Lee, Juhyon J.; Albrecht, Merwe; Rice, Corey A.; Suhm, Martin A.
- Jet-cooled infrared spectra of acetylated glycine, alanine, and dialanine esters and their dimers are reported in the amide A and amide I-III regions. They serve as particularly simple peptide aggregation models and are found to prefer a single backbone conformation in the dimer that is different from the most stable monomer backbone conformation. In the case of alanine, evidence for topology-changing chirality discrimination upon dimer formation is found. The jet spectroscopic results are compared to gas phase spectra and quantum chemical calculations. They provide reliable benchmarks for the evaluation of the latter in the field of peptide interactions.
- Issue Date
- Amer Chemical Soc
- The Journal of Physical Chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory
- Institut für Physikalische Chemie
- Fonds der Chemischen Industrie; DFG research training group 782