Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication

2013 | journal article. A publication with affiliation to the University of Göttingen.

Jump to: Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte-Neuron Communication​
Fruehbeis, C.; Froehlich, D.; Kuo, W. P.; Amphornrat, J.; Thilemann, S.; Saab, A. S. & Kirchhoff, F. et al.​ (2013) 
PLoS Biology11(7) art. e1001604​.​ DOI: 

Documents & Media

journal.pbio.1001604.pdf9.78 MBAdobe PDF


Published Version

Attribution-NonCommercial 3.0 CC BY-NC 3.0


Fruehbeis, Carsten; Froehlich, Dominik; Kuo, Wen Ping; Amphornrat, Jesa; Thilemann, Sebastian; Saab, Aiman S.; Kirchhoff, Frank; Möbius, Wiebke ; Goebbels, Sandra; Nave, Klaus-Armin; Schneider, Anja; Simons, Mikael; Klugmann, Matthias; Trotter, Jacqueline; Kraemer-Albers, Eva-Maria
Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of axons occurs in several human myelin diseases, however the molecular mechanisms of axon-glia communication maintaining axon integrity are poorly understood. Here, we describe the signal-mediated transfer of exosomes from oligodendrocytes to neurons. These endosome-derived vesicles are secreted by oligodendrocytes and carry specific protein and RNA cargo. We show that activity-dependent release of the neurotransmitter glutamate triggers oligodendroglial exosome secretion mediated by Ca2+ entry through oligodendroglial NMDA and AMPA receptors. In turn, neurons internalize the released exosomes by endocytosis. Injection of oligodendroglia-derived exosomes into the mouse brain results in functional retrieval of exosome cargo in neurons. Supply of cultured neurons with oligodendroglial exosomes improves neuronal viability under conditions of cell stress. These findings indicate that oligodendroglial exosomes participate in a novel mode of bidirectional neuron-glia communication contributing to neuronal integrity.
Issue Date
Public Library Science
PLoS Biology 



Social Media