Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking

2014 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​Quantification of Left Ventricular Torsion and Diastolic Recoil Using Cardiovascular Magnetic Resonance Myocardial Feature Tracking​
Kowallick, J. T. ; Lamata, P.; Hussain, S. T.; Kutty, S.; Steinmetz, M. ; Sohns, J. M.   & Fasshauer, M.  et al.​ (2014) 
PLoS ONE9(10) art. e109164​.​ DOI: https://doi.org/10.1371/journal.pone.0109164 

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Kowallick, Johannes Tammo ; Lamata, Pablo; Hussain, Shazia T.; Kutty, Shelby; Steinmetz, Michael ; Sohns, Jan Martin ; Fasshauer, Martin ; Staab, Wieland ; Unterberg-Buchwald, Christina ; Bigalke, Boris; Lotz, Joachim ; Hasenfuß, Gerd ; Schuster, Andreas 
Objectives: Cardiovascular magnetic resonance feature tracking (CMR-FT) offers quantification of myocardial deformation from routine cine images. However, data using CMR-FT to quantify left ventricular (LV) torsion and diastolic recoil are not yet available. We therefore sought to evaluate the feasibility and reproducibility of CMR-FT to quantify LV torsion and peak recoil rate using an optimal anatomical approach. Methods: Short-axis cine stacks were acquired at rest and during dobutamine stimulation (10 and 20 mu g.kg(-1).min(-1)) in 10 healthy volunteers. Rotational displacement was analysed for all slices. A complete 3D-LV rotational model was developed using linear interpolation between adjacent slices. Torsion was defined as the difference between apical and basal rotation, divided by slice distance. Depending on the distance between the most apical (defined as 0% LV distance) and basal (defined as 100% LV distance) slices, four different models for the calculation of torsion were examined: Model-1 (25-75%), Model-2 (0-100%), Model-3 (25-100%) and Model-4 (0-75%). Analysis included subendocardial, subepicardial and global torsion and recoil rate (mean of subendocardial and subepicardial values). Results: Quantification of torsion and recoil rate was feasible in all subjects. There was no significant difference between the different models at rest. However, only Model-1 (25-75%) discriminated between rest and stress (Global Torsion: 2.7 +/- 1.5 degrees cm(-1), 3.6 +/- 2.0 degrees cm(-1), 5.1 +/- 2.2 degrees cm(-1), p<0.01; Global Recoil Rate: -30.1 +/- 11.1 degrees cm(-1) s (-1), -469 +/- 15.0 degrees cm (-1) s (-1), -68.9 +/- 32.3 degrees cm(-1) s(-1), p<0.01; for rest, 10 and 20 mu g.kg(-1).min(-1) of dobutamine, respectively). Reproducibility was sufficient for all parameters as determined by Bland-Altman analysis, intraclass correlation coefficients and coefficient of variation. Conclusions: CMR-FT based derivation of myocardial torsion and recoil rate is feasible and reproducible at rest and with dobutamine stress. Using an optimal anatomical approach measuring rotation at 25% and 75% apical and basal LV locations allows effective quantification of torsion and recoil dynamics. Application of these new measures of deformation by CMR-FT should next be explored in disease states.
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Public Library Science
Open-Access-Publikationsfonds 2014



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