Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy

2004 | journal article. A publication of Göttingen

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​Stroke-like pattern in DTI and MRS of childhood mitochondrial leukoencephalopathy​
Brockmann, K. ; Finsterbusch, J.; Schara, U.; Wilichowski, E. ; Frahm, J.   & Hanefeld, F.​ (2004) 
Neuroradiology46(4) pp. 267​-271​.​ DOI: https://doi.org/10.1007/s00234-004-1181-7 

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Authors
Brockmann, Knut ; Finsterbusch, Jürgen; Schara, Ulrike; Wilichowski, Ekkehard ; Frahm, Jens ; Hanefeld, Folker
Abstract
In a 13-month-old boy with recurrent motor deterioration provoked by fever MRI and proton MRS detected a leukoencephalopathy with reduced cerebral metabolites and elevated lactate. At follow-up 6 and 16 months later these abnormalities improved gradually. Serial diffusion tensor imaging revealed a stroke-like pattern with an initial strong reduction of the apparent diffusion coefficient followed by elevated values 6 months later. The relative diffusion anisotropy remained reduced. Muscle biopsy confirmed a mitochondrial encephalomyopathy.
Issue Date
2004
Journal
Neuroradiology 
ISSN
0028-3940

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