Survival of adult neurons lacking cholesterol synthesis in vivo

2007 | journal article. A publication with affiliation to the University of Göttingen.

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​Survival of adult neurons lacking cholesterol synthesis in vivo​
Fünfschilling, U.; Saher, G.; Xiao, L.; Möbius, W.   & Nave, K.-A.​ (2007) 
BMC Neuroscience8(1) pp. 1​-9​.​ DOI: 

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Fünfschilling, Ursula; Saher, Gesine; Xiao, Le; Möbius, Wiebke ; Nave, Klaus-Armin
Background: Cholesterol, an essential component of all mammalian plasma membranes, is highly enriched in the brain. Both during development and in the adult, brain cholesterol is derived from local cholesterol synthesis and not taken up from the circulation. However, the contribution of neurons and glial cells to total brain cholesterol metabolism is unknown.Results: Using conditional gene inactivation in the mouse, we disrupted the squalene synthase gene (fdft1), which is critical for cholesterol synthesis, in cerebellar granule cells and some precerebellar nuclei. Mutant mice showed no histological signs of neuronal degeneration, displayed ultrastructurally normal synapses, and exhibited normal motor coordination. This revealed that these adult neurons do not require cell-autonomous cholesterol synthesis for survival or function.
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BMC Neuroscience 



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