Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin

2017 | journal article. A publication with affiliation to the University of Göttingen.

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​Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin​
Snaidero, N.; Velte, C.; Myllykoski, M.; Raasakka, A.; Ignatev, A.; Werner, H. B. & Erwig, M. S. et al.​ (2017) 
Cell Reports18(2) pp. 314​-323​.​ DOI: 

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Snaidero, Nicolas; Velte, Caroline; Myllykoski, Matti; Raasakka, Arne; Ignatev, Alexander; Werner, Hauke B.; Erwig, Michelle S.; Möbius, Wiebke ; Kursula, Petri; Nave, Klaus-Armin; Simons, Mikael
The myelin sheath is a multilamellar plasma membrane extension of highly specialized glial cells laid down in regularly spaced segments along axons. Recent studies indicate that myelin is metabolically active and capable of communicating with the underlying axon. To be functionally connected to the neuron, oligodendrocytes maintain non-compacted myelin as cytoplasmic nanochannels. Here, we used high-pressure freezing for electron microscopy to study these cytoplasmic regions within myelin close to their native state. We identified 2,030-cyclic nucleotide 30-phosphodiesterase (CNP), an oligodendrocyte- specific protein previously implicated in the maintenance of axonal integrity, as an essential factor in generating and maintaining cytoplasm within the myelin compartment. We provide evidence that CNP directly associates with and organizes the actin cytoskeleton, thereby providing an intracellular strut that counteracts membrane compaction by myelin basic protein (MBP). Our study provides amolecular and structural framework for understanding how myelin maintains its cytoplasm to function as an active axon-glial unit.
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Cell Reports 
info:eu-repo/grantAgreement/EC/FP7/647168/EU/Cell biology of myelin wrapping, plasticity and turnover/Myelination
info:eu-repo/grantAgreement/EC/FP7/269020/EU/The role of myelinating glia in preserving axon function/AXOGLIA
info:eu-repo/grantAgreement/EC/FP7/671048/EU/Myelinic nanochannels in neurodegenerative diseases/MyeliNANO



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