Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis

2018 | journal article. A publication with affiliation to the University of Göttingen.

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​Low-oxygen response is triggered by an ATP-dependent shift in oleoyl-CoA in Arabidopsis​
Schmidt, R. R.; Fulda, M.; Paul, M. V.; Anders, M.; Plum, F.; Weits, D. A. & Kosmacz, M. et al.​ (2018) 
Proceedings of the National Academy of Sciences of the United States of America115(51) art. E12101​.​ DOI: https://doi.org/10.1073/pnas.1809429115 

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Authors
Schmidt, Romy R.; Fulda, Martin; Paul, Melanie V.; Anders, Max; Plum, Frederic; Weits, Daniel A.; Kosmacz, Monika; Larson, Tony R.; Graham, Ian A.; Beemster, Gerrit T. S.; Licausi, Francesco; Geigenberger, Peter; Schippers, Jos H.; van Dongen, Joost T.
Abstract
Plant response to environmental stimuli involves integration of multiple signals. Upon low-oxygen stress, plants initiate a set of adaptive responses to circumvent an energy crisis. Here, we reveal how these stress responses are induced by combining (i) energy-dependent changes in the composition of the acyl-CoA pool and (ii) the cellular oxygen concentration. A hypoxia-induced decline of cellular ATP levels reduces LONG-CHAIN ACYL-COA SYNTHETASE activity, which leads to a shift in the composition of the acyl-CoA pool. Subsequently, we show that different acyl-CoAs induce unique molecular responses. Altogether, our data disclose a role for acyl-CoAs acting in a cellular signaling pathway in plants. Upon hypoxia, high oleoyl-CoA levels provide the initial trigger to release the transcription factor RAP2.12 from its interaction partner ACYL-COA BINDING PROTEIN at the plasma membrane. Subsequently, according to the N-end rule for proteasomal degradation, oxygen concentration-dependent stabilization of the subgroup VII ETHYLENE-RESPONSE FACTOR transcription factor RAP2.12 determines the level of hypoxia-specific gene expression. This research unveils a specific mechanism activating low-oxygen stress responses only when a decrease in the oxygen concentration coincides with a drop in energy.
Issue Date
2018
Journal
Proceedings of the National Academy of Sciences of the United States of America 
Organization
Albrecht-von-Haller-Institut für Pflanzenwissenschaften 
ISSN
1091-6490
Language
English

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