IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses

2018 | Zeitschriftenartikel; Forschungsarbeit. Eine Publikation mit Affiliation zur Georg-August-Universität Göttingen.

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​IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses​
Babaev, O.; Cruces-Solis, H.; Piletti Chatain, C.; Hammer, M.; Wenger, S.; Ali, H. & Karalis, N. u.a.​ (2018) 
Nature Communications9(1) art. 5400​.​ DOI: https://doi.org/10.1038/s41467-018-07762-1 

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Autor(en)
Babaev, Olga; Cruces-Solis, Hugo; Piletti Chatain, Carolina; Hammer, Matthieu; Wenger, Sally; Ali, Heba; Karalis, Nikolaos; de Hoz, Livia; Schlüter, Oliver M. ; Yanagawa, Yuchio; Ehrenreich, Hannelore; Taschenberger, Holger; Brose, Nils ; Krueger-Burg, Dilja
Zusammenfassung
Abnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural circuits and behaviors. Here we study the role of IgSF9b, an adhesion protein that has been associated with affective disorders, in the amygdala anxiety circuitry. We show that deletion of IgSF9b normalizes anxiety-related behaviors and neural processing in mice lacking the synapse organizer Neuroligin-2 (Nlgn2), which was proposed to complex with IgSF9b. This normalization occurs through differential effects of Nlgn2 and IgSF9b at inhibitory synapses in the basal and centromedial amygdala (CeM), respectively. Moreover, deletion of IgSF9b in the CeM of adult Nlgn2 knockout mice has a prominent anxiolytic effect. Our data place IgSF9b as a key regulator of inhibition in the amygdala and indicate that IgSF9b-expressing synapses in the CeM may represent a target for anxiolytic therapies.
Erscheinungsdatum
2018
Zeitschrift
Nature Communications 
Project
info:eu-repo/grantAgreement/EC/FP7/213342/EU//AIMS
SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente 
SFB 1190 | P10: Rekrutierung und Verankerung von Neurotransmitterrezeptoren an GABAergen Synapsen - Zellbiologie und molekulare Mechanismen 
Organisation
Max-Planck-Institut für Experimentelle Medizin ; Göttinger Graduiertenzentrum für Neurowissenschaften, Biophysik und Molekulare Biowissenschaften ; European Neuroscience Institute Göttingen 
Arbeitsgruppe
RG Brose 
ISSN
2041-1723
Sprache
Englisch

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