From TOM to the TIM23 complex - handing over of a precursor

2020-03-09 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​From TOM to the TIM23 complex - handing over of a precursor​
Callegari, S.; Cruz-Zaragoza, L. D. & Rehling, P. ​ (2020) 
Biological Chemistry,.​ DOI: https://doi.org/10.1515/hsz-2020-0101 

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Authors
Callegari, Sylvie; Cruz-Zaragoza, Luis Daniel; Rehling, Peter 
Abstract
Mitochondrial precursor proteins with amino-terminal presequences are imported via the presequence pathway, utilizing the TIM23 complex for inner membrane translocation. Initially, the precursors pass the outer membrane through the TOM complex and are handed over to the TIM23 complex where they are sorted into the inner membrane or translocated into the matrix. This handover process depends on the receptor proteins at the inner membrane, Tim50 and Tim23, which are critical for efficient import. In this review, we summarize key findings that shaped the current concepts of protein translocation along the presequence import pathway, with a particular focus on the precursor handover process from TOM to the TIM23 complex. In addition, we discuss functions of the human TIM23 pathway and the recently uncovered pathogenic mutations in TIM50.
Issue Date
9-March-2020
Journal
Biological Chemistry 
Project
SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente 
SFB 1190 | P13: Protein Transport über den mitochondrialen Carrier Transportweg 
Working Group
RG Rehling (Mitochondrial Protein Biogenesis) 
External URL
https://sfb1190.med.uni-goettingen.de/production/literature/publications/198
ISSN
1437-4315; 1431-6730
eISSN
1437-4315
Language
English

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