A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain

2005 | journal article

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​A hematopoietic growth factor, thrombopoietin, has a proapoptotic role in the brain​
Hasselblatt, M. ; Knerlich, F. ; von Ahsen, N. ; Jacob, S. ; Sperling, S. ; Woldt, H.   & Vehmeyer, K.  et al.​ (2005) 
Proceedings of the National Academy of Sciences of the United States of America102(3) pp. 862​-867​.​ DOI: https://doi.org/10.1073/pnas.0406008102 

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Authors
Hasselblatt, Martin ; Knerlich, Friederike ; von Ahsen, N. ; Jacob, Sonja ; Sperling, S. ; Woldt, H. ; Vehmeyer, K. ; Nave, Klaus-Armin ; Sirén, A.-L. ; Ehrenreich, H. 
Abstract
Central nervous and hematopoietic systems share developmental features. We report that thrombopoietin (TPO), a stimulator of platelet formation, acts in the brain as a counterpart of erythropoietin (EPO), a hematopoietic growth factor with neuroprotective properties. TPO is most prominent in postnatal brain, whereas EPO is abundant in embryonic brain and decreases postnatally. Upon hypoxia, EPO and its receptor are rapidly reexpressed, whereas neuronal TPO and its receptor are down-regulated. Unexpectedly, TPO is strongly proapoptotic in the brain, causing death of newly generated neurons through the Ras-extracellular signal-regulated kinase 1/2 pathway. This effect is not only inhibited by EPO but also by neurotrophins. We suggest that the proapoptotic function of TPO helps to select for neurons that have acquired target-derived neurotrophic support.
Issue Date
2005
Journal
Proceedings of the National Academy of Sciences of the United States of America 
ISSN
0027-8424
Language
English

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