Reentrant liquid-liquid phase separation in protein solutions at elevated hydrostatic pressures

2014-01-17 | journal article; research paper

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​Möller, J., Grobelny, S., Schulze, J., Bieder, S., Steffen, A., Erlkamp, M., Paulus, M. ... Winter, R. (2014). ​Reentrant liquid-liquid phase separation in protein solutions at elevated hydrostatic pressures. Physical Review Letters112(2), Article 028101​. ​doi: https://doi.org/10.1103/PhysRevLett.112.028101 

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Authors
Möller, Johannes; Grobelny, Sebastian; Schulze, Julian; Bieder, Steffen; Steffen, Andre; Erlkamp, Mirko; Paulus, Michael; Tolan, Metin ; Winter, Roland
Abstract
We present results from small-angle x-ray scattering data on the effect of high pressure on the phase behavior of dense lysozyme solutions in the liquid-liquid phase separation region, and characterize the underlying intermolecular protein-protein interactions as a function of temperature and pressure in this region of phase space. A reentrant liquid-liquid phase separation region has been discovered at elevated pressures, which originates in the pressure dependence of the solvent-mediated protein-protein interactions.
Issue Date
17-January-2014
Journal
Physical Review Letters 
ISSN
0031-9007
eISSN
1079-7114
Language
English

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