Reentrant liquid-liquid phase separation in protein solutions at elevated hydrostatic pressures
2014-01-17 | journal article; research paper
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Reentrant liquid-liquid phase separation in protein solutions at elevated hydrostatic pressures
Möller, J.; Grobelny, S.; Schulze, J.; Bieder, S.; Steffen, A.; Erlkamp, M. & Paulus, M. et al. (2014)
Physical Review Letters, 112(2) art. 028101. DOI: https://doi.org/10.1103/PhysRevLett.112.028101
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Details
- Authors
- Möller, Johannes; Grobelny, Sebastian; Schulze, Julian; Bieder, Steffen; Steffen, Andre; Erlkamp, Mirko; Paulus, Michael; Tolan, Metin ; Winter, Roland
- Abstract
- We present results from small-angle x-ray scattering data on the effect of high pressure on the phase behavior of dense lysozyme solutions in the liquid-liquid phase separation region, and characterize the underlying intermolecular protein-protein interactions as a function of temperature and pressure in this region of phase space. A reentrant liquid-liquid phase separation region has been discovered at elevated pressures, which originates in the pressure dependence of the solvent-mediated protein-protein interactions.
- Issue Date
- 17-January-2014
- Journal
- Physical Review Letters
- ISSN
- 0031-9007
- eISSN
- 1079-7114
- Language
- English
