Otoferlin: a multi-C-2 domain protein essential for hearing

2012 | review. A publication with affiliation to the University of Göttingen.

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​Otoferlin: a multi-C-2 domain protein essential for hearing​
Pangršič, T. ; Reisinger, E.  & Moser, T. ​ (2012)
Trends in Neurosciences, 35​(11) pp. 671​-680​.​
Elsevier Science London. DOI: https://doi.org/10.1016/j.tins.2012.08.002 

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Authors
Pangršič, Tina ; Reisinger, Ellen ; Moser, Tobias 
Abstract
Sound is encoded at synapses between cochlear inner hair cells and the auditory nerve. These synapses are anatomically and functionally specialized to transmit acoustic information with high fidelity over a lifetime. The molecular mechanisms of hair-cell transmitter release have recently attracted substantial interest. Here we review progress toward understanding otoferlin, a multi-C-2 domain protein identified a decade ago by genetic analysis of human deafness. Otoferlin functions in hair-cell exocytosis. Several otoferlin C-2 domains bind to Ca2+, phospholipids, and proteins. Current research reveals requirements for otoferlin in priming and fusion of synaptic vesicles during sound encoding. Understanding the molecular mechanisms through which otoferlin functions also has important implications for understanding the disease mechanisms that lead to deafness.
Issue Date
2012
Publisher
Elsevier Science London
Journal
Trends in Neurosciences 
ISSN
0166-2236

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