Vimentin protects differentiating stem cells from stress

2020 | journal article; research paper. A publication with affiliation to the University of Göttingen.

Jump to: Cite & Linked | Documents & Media | Details | Version history

Cite this publication

​Vimentin protects differentiating stem cells from stress​
Pattabiraman, S.; Azad, G. K.; Amen, T.; Brielle, S.; Park, J. E.; Sze, S. K. & Meshorer, E. et al.​ (2020) 
Scientific Reports10(1).​ DOI: https://doi.org/10.1038/s41598-020-76076-4 

Documents & Media

s41598-020-76076-4.pdf1.92 MBAdobe PDF

License

Published Version

Usage license

Details

Authors
Pattabiraman, Sundararaghavan; Azad, Gajendra Kumar; Amen, Triana; Brielle, Shlomi; Park, Jung Eun; Sze, Siu Kwan; Meshorer, Eran; Kaganovich, Daniel
Abstract
Abstract Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.
Issue Date
2020
Journal
Scientific Reports 
Organization
Abteilung Experimentelle Neurodegeneration 
eISSN
2045-2322
Language
English
Sponsor
Open-Access-Publikationsfonds 2021

Reference

Citations


Social Media