Vimentin protects differentiating stem cells from stress
2020 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Cite this publication
Pattabiraman, S., Azad, G. K., Amen, T., Brielle, S., Park, J. E., Sze, S. K., Meshorer, E. ... Kaganovich, D. (2020). Vimentin protects differentiating stem cells from stress. Scientific Reports, 10(1), . doi: https://doi.org/10.1038/s41598-020-76076-4
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Details
- Authors
- Pattabiraman, Sundararaghavan; Azad, Gajendra Kumar; Amen, Triana; Brielle, Shlomi; Park, Jung Eun; Sze, Siu Kwan; Meshorer, Eran; Kaganovich, Daniel
- Abstract
- Abstract Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.
- Issue Date
- 2020
- Journal
- Scientific Reports
- Organization
- Abteilung Experimentelle Neurodegeneration
- eISSN
- 2045-2322
- Language
- English
- Sponsor
- Open-Access-Publikationsfonds 2021