Vimentin protects differentiating stem cells from stress
2020 | journal article; research paper. A publication with affiliation to the University of Göttingen.
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Vimentin protects differentiating stem cells from stress
Pattabiraman, S.; Azad, G. K.; Amen, T.; Brielle, S.; Park, J. E.; Sze, S. K. & Meshorer, E. et al. (2020)
Scientific Reports, 10(1). DOI: https://doi.org/10.1038/s41598-020-76076-4
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Details
- Authors
- Pattabiraman, Sundararaghavan; Azad, Gajendra Kumar; Amen, Triana; Brielle, Shlomi; Park, Jung Eun; Sze, Siu Kwan; Meshorer, Eran; Kaganovich, Daniel
- Abstract
- Abstract Vimentin is one of the first cytoplasmic intermediate filaments to be expressed in mammalian cells during embryogenesis, but its role in cellular fitness has long been a mystery. Vimentin is acknowledged to play a role in cell stiffness, cell motility, and cytoplasmic organization, yet it is widely considered to be dispensable for cellular function and organismal development. Here, we show that Vimentin plays a role in cellular stress response in differentiating cells, by recruiting aggregates, stress granules, and RNA-binding proteins, directing their elimination and asymmetric partitioning. In the absence of Vimentin, pluripotent embryonic stem cells fail to differentiate properly, with a pronounced deficiency in neuronal differentiation. Our results uncover a novel function for Vimentin, with important implications for development, tissue homeostasis, and in particular, stress response.
- Issue Date
- 2020
- Journal
- Scientific Reports
- Organization
- Abteilung Experimentelle Neurodegeneration
- eISSN
- 2045-2322
- Language
- English
- Sponsor
- Open-Access-Publikationsfonds 2021