Structure and function of SARS-CoV-2 polymerase

2021 | journal article; overview. A publication with affiliation to the University of Göttingen.

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​Structure and function of SARS-CoV-2 polymerase​
Hillen, H. S. ​ (2021) 
Current Opinion in Virology48 pp. 82​-90​.​ DOI: https://doi.org/10.1016/j.coviro.2021.03.010 

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Authors
Hillen, Hauke S. 
Abstract
Coronaviruses use an RNA-dependent RNA polymerase (RdRp) to replicate and express their genome. The RdRp associates with additional non-structural proteins (nsps) to form a replication–transcription complex (RTC) that carries out RNA synthesis, capping and proofreading. However, the structure of the RdRp long remained elusive, thus limiting our understanding of coronavirus genome expression and replication. Recently, the cryo-electron microscopy structure of SARS-CoV-1 RdRp was reported. Driven by the ongoing COVID-19 pandemic, structural data on the SARS-CoV-2 polymerase and associated factors has since emerged at an unprecedented pace, with more than twenty structures released to date. This review provides an overview of the currently available coronavirus RdRp structures and outlines how they have, together with functional studies, led to a molecular understanding of the viral polymerase, its interactions with accessory factors and the mechanisms by which promising antivirals may inhibit coronavirus replication.
Issue Date
2021
Journal
Current Opinion in Virology 
Project
EXC 2067: Multiscale Bioimaging 
SFB 1190: Transportmaschinen und Kontaktstellen zellulärer Kompartimente 
FOR 2848: Architektur und Heterogenität der inneren mitochondrialen Membran auf der Nanoskala 
FOR 2848 | St01: Structure and distribution of ribosomes at the inner mitochondrial membrane 
Working Group
RG Hillen (Structure and Function of Molecular Machines) 
External URL
https://mbexc.uni-goettingen.de/literature/publications/247
https://sfb1190.med.uni-goettingen.de/production/literature/publications/142
https://for2848.gwdguser.de/literature/publications/15
ISSN
1879-6257
Language
English

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