Aggregopathy in neurodegenerative diseases: Mechanisms and therapeutic implication

2008 | review. A publication with affiliation to the University of Göttingen.

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​Aggregopathy in neurodegenerative diseases: Mechanisms and therapeutic implication​
Dohm, C. P. ; Kermer, P.  & Bähr, M. ​ (2008)
Neurodegenerative Diseases, 5​(6) pp. 321​-338​.​ DOI: https://doi.org/10.1159/000119459 

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Authors
Dohm, C. P. ; Kermer, P. ; Bähr, M. 
Abstract
Many neurodegenerative diseases such as Parkinson's, Alzheimer's, Huntington's and Lou Gehrig's disease are associated with the misfolding and aggregation of proteins. While the relevance of these aggregates for neuronal degeneration and their impact on cellular function is still a matter of debate, several experimental therapeutic approaches have been aimed at interfering with protein aggregation. In this review, we want to summarize the current understanding of aggregate formation and toxicity in neurodegenerative diseases with an emphasis on Parkinson's disease. Furthermore, we will discuss current treatment strategies in these diseases targeting aggregate formation and concurrent neuronal cell death in these diseases. Copyright (C) 2008 S. Karger AG, Basel.
Issue Date
2008
Journal
Neurodegenerative Diseases 
ISSN
1660-2854
eISSN
1660-2862
Language
English

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