TY - JOUR AU - AU - Babaev, Olga AU - Cruces-Solis, Hugo AU - Piletti Chatain, Carolina AU - Hammer, Matthieu AU - Wenger, Sally AU - Ali, Heba AU - Karalis, Nikolaos AU - de Hoz, Livia AU - Schlüter, Oliver M. AU - Yanagawa, Yuchio AU - Ehrenreich, Hannelore AU - Taschenberger, Holger AU - Brose, Nils AU - Krueger-Burg, Dilja T1 - IgSF9b regulates anxiety behaviors through effects on centromedial amygdala inhibitory synapses PY - 2018 N2 - Abnormalities in synaptic inhibition play a critical role in psychiatric disorders, and accordingly, it is essential to understand the molecular mechanisms linking components of the inhibitory postsynapse to psychiatrically relevant neural circuits and behaviors. Here we study the role of IgSF9b, an adhesion protein that has been associated with affective disorders, in the amygdala anxiety circuitry. We show that deletion of IgSF9b normalizes anxiety-related behaviors and neural processing in mice lacking the synapse organizer Neuroligin-2 (Nlgn2), which was proposed to complex with IgSF9b. This normalization occurs through differential effects of Nlgn2 and IgSF9b at inhibitory synapses in the basal and centromedial amygdala (CeM), respectively. Moreover, deletion of IgSF9b in the CeM of adult Nlgn2 knockout mice has a prominent anxiolytic effect. Our data place IgSF9b as a key regulator of inhibition in the amygdala and indicate that IgSF9b-expressing synapses in the CeM may represent a target for anxiolytic therapies. UR - https://sfb1190.med.uni-goettingen.de/production/literature/publications/49 DO - doi:10.1038/s41467-018-07762-1 LA - en ER -