Lipopolysaccharide Injection Induces Relapses of Experimental Autoimmune Encephalomyelitis in Nontransgenic Mice via Bystander Activation of Autoreactive CD4 + Cells
2005 | journal article. A publication with affiliation to the University of Göttingen.
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Lipopolysaccharide Injection Induces Relapses of Experimental Autoimmune Encephalomyelitis in Nontransgenic Mice via Bystander Activation of Autoreactive CD4 + Cells
Nogai, A.; Siffrin, V.; Bonhagen, K.; Pfueller, C. F.; Hohnstein, T.; Volkmer-Engert, R. & Brück, W. et al. (2005)
The Journal of Immunology, 175(2) pp. 959-966. DOI: https://doi.org/10.4049/jimmunol.175.2.959
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- Authors
- Nogai, Axel; Siffrin, Volker; Bonhagen, Kerstin; Pfueller, Caspar F.; Hohnstein, Thordis; Volkmer-Engert, Rudolf; Brück, Wolfgang; Stadelmann, Christine ; Kamradt, Thomas
- Abstract
- Infections sometimes associate with exacerbations of autoimmune diseases through pathways that are poorly understood. Ag-specific mechanisms such as cross-reactivity between a microbial Ag and a self-Ag have received no direct support. In this study, we show that injection of LPS induces experimental autoimmune encephalomyelitis in TCR-transgenic mice and relapse of encephalomyelitis in normal mice. This form of treatment induces proliferation and cytokine production in a fraction of effector/memory Th lymphocytes in vitro via physical contact of Th cells with CD4(-) LPS-responsive cells. TCR-mediated signals are not necessary; rather what is required is ligation of costimulatory receptors on Th cells by costimulatory molecules on the CD4- cells. This form of bystander activation provides an Ag-independent link between infection and autoimmunity that might fit the clinical and epidemiological data on the connection between infection and autoimmunity better than the Ag-specific models.
- Issue Date
- 2005
- Status
- published
- Publisher
- Amer Assoc Immunologists
- Journal
- The Journal of Immunology
- ISSN
- 0022-1767
- eISSN
- 1550-6606
- Language
- English