Harmonin inhibits presynaptic Ca(v)1.3 Ca2+ channels in mouse inner hair cells

2011 | journal article; research paper. A publication with affiliation to the University of Göttingen.

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​Harmonin inhibits presynaptic Ca(v)1.3 Ca2+ channels in mouse inner hair cells​
Gregory, F. D.; Bryan, K. E.; Pangršič, T. ; Calin-Jageman, I. E.; Moser, T.   & Lee, A.​ (2011) 
Nature Neuroscience, 14(9) pp. 1109​-1111​.​ DOI: https://doi.org/10.1038/nn.2895 

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Authors
Gregory, Frederick D.; Bryan, Keith E.; Pangršič, Tina ; Calin-Jageman, Irina E.; Moser, Tobias ; Lee, Amy
Abstract
Harmonin is a scaffolding protein that is required for normal mechanosensory function in hair cells. We found a presynaptic association of harmonin and Ca(v)1.3 Ca2+ channels at the mouse inner hair cell synapse, which limits channel availability through a ubiquitin-dependent pathway.
Issue Date
2011
Publisher
Nature Publishing Group
Journal
Nature Neuroscience 
ISSN
1097-6256

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