The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis
2010-08-05 | journal article; research paper
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The transcription factor Rbf1 is the master regulator for b-mating type controlled pathogenic development in Ustilago maydis
Heimel, K. ; Scherer, M.; Vranes, M.; Wahl, R.; Pothiratana, C.; Schuler, D. & Vincon, V. et al. (2010)
PLoS Pathogens, 6(8) art. e1001035. DOI: https://doi.org/10.1371/journal.ppat.1001035
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Details
- Authors
- Heimel, Kai ; Scherer, Mario; Vranes, Miroslav; Wahl, Ramon; Pothiratana, Chetsada; Schuler, David; Vincon, Volker; Finkernagel, Florian; Flor-Parra, Ignacio; Kämper, Jörg
- Abstract
- In the phytopathogenic basidiomycete Ustilago maydis, sexual and pathogenic development are tightly connected and controlled by the heterodimeric bE/bW transcription factor complex encoded by the b-mating type locus. The formation of the active bE/bW heterodimer leads to the formation of filaments, induces a G2 cell cycle arrest, and triggers pathogenicity. Here, we identify a set of 345 bE/bW responsive genes which show altered expression during these developmental changes; several of these genes are associated with cell cycle coordination, morphogenesis and pathogenicity. 90% of the genes that show altered expression upon bE/bW-activation require the zinc finger transcription factor Rbf1, one of the few factors directly regulated by the bE/bW heterodimer. Rbf1 is a novel master regulator in a multilayered network of transcription factors that facilitates the complex regulatory traits of sexual and pathogenic development.
- Issue Date
- 5-August-2010
- Journal
- PLoS Pathogens
- eISSN
- 1553-7374
- Language
- English